Evidence map›Paper›PMID 41068949›Full record

ArticleChinese neurosurgical journal2025

Composition of carotid plaques differs between Chinese and US patients: a histology study.

Jingli Cao, Marina Ferguson, Jie Sun, Mi Shen, Randy Small, Daniel S Hippe, Xihai Zhao, Dong Zhang, Hiroko Watase, Chun Yuan and 10 more

Abstract read
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In one paragraph

Article in Chinese neurosurgical journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

20 authors.

Jingli CaoChina National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China.
Marina FergusonVascular Imaging Laboratory, Department of Radiology, University of Washington, Seattle, WA, 98195, USA.
Jie SunVascular Imaging Laboratory, Department of Radiology, University of Washington, Seattle, WA, 98195, USA.
Mi ShenDepartment of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China.
Randy SmallDepartment of Pathology, University of Washington, Seattle, WA, 98195, USA.
Daniel S HippeClinical Biostatistics, Clinical Research Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Xihai ZhaoDepartment of Biomedical Engineering, Center for Biomedical Imaging Research, School of Medicine, Tsinghua University, Beijing, 100084, China.
Dong ZhangDepartment of Neurosurgery, Beijing Tiantan Hospital, Beijing Neurosurgical Institute, Capital Medical University, Beijing, 100070, China.
Hiroko WataseDepartment of Surgery, University of Washington, Seattle, WA, 98195, USA.
Chun YuanVascular Imaging Laboratory, Department of Radiology, University of Washington, Seattle, WA, 98195, USA.
Peiyi GaoDepartment of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China.
James Kevin DeMarcoThe Department of Radiology, Walter Reed National Military Medical Center, Uniformed Services University of Health Sciences, Bethesda, MD, 20889, USA.
Roberto F NicosiaDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle, 98195, USA.
Yajie WangDepartment of Clinical Laboratory, Beijing Ditan Hospital, Capital Medical University, Beijing, 100015, China.
Haowen LiChina National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China.
Zirui LiChina National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China.
Yi WangChina National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China.
Ted KohlerDepartment of Surgery, University of Washington, Seattle, WA, 98195, USA.
Thomas HatsukamiDepartment of Surgery, University of Washington, Seattle, WA, 98195, USA. tomhat@uw.edu.
Binbin SuiChina National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China. reneesui@163.com.

Funding

Carotid Intraplaque Hemorrhage: MRI of Therapeutic Response and Clinical SequelaeR01HL103609 · NHLBI · UNIVERSITY OF WASHINGTON · PI HATSUKAMI, THOMAS, YUAN, CHUN · 2011 to 2021
$7.1M
Magnetic Resonance Imaging of Vulnerable PlaqueR01HL073401 · NHLBI · UNIVERSITY OF WASHINGTON · PI HATSUKAMI, THOMAS · 2003 to 2006
$2.3M
Culprit Plaque in Acute Cerebral Infarction: A Histological and MRI AssessmentR01NS083503 · NINDS · UNIVERSITY OF WASHINGTON · PI HATSUKAMI, THOMAS · 2013 to 2015
$598k
Beijing Natural Science Foundation L232130National Natural Science Foundation of China 81361120402 and 62271061NHLBI NIH HHS R01 HL073401NHLBI NIH HHS R01 HL103609NIH HHS R01 NS083503, R01 HL61851, R01-HL60213, RO1 HL073401, and R01 HL103609NINDS NIH HHS R01 NS083503
6 · The paper itself

Abstract

backgroundThe clinical manifestations of cerebrovascular disease are known to differ between the Chinese and United States (US) populations as do the plaque features on imaging.

objectivesThe aim of this study was to investigate and compare the histological features of excised carotid plaques from Chinese and US patients.

methodsCarotid endarterectomy specimens collected from two prospective studies were included. The entire plaque was serially sectioned (10-µm thickness) at 0.5-1 mm intervals. Hematoxylin and eosin staining and Mallory's trichrome staining were performed. The morphology and components of the plaques were measured and compared between the two groups.

resultsA total of 1152 histological sections from 75 Chinese patients and 1843 sections from 111 US patients were analyzed. The Chinese group had significantly smaller minimum lumen diameters (median: 1.1 vs. 1.3 mm, p = 0.046) and a larger percent wall volume (median: 74% vs. 70%, p = 0.018) than the US group. After adjusting for confounding factors, carotid plaques in the Chinese population had larger lipid pools (β = 10.0%, 95% CI: 4.9 to 15.9%), more recent intraplaque hemorrhage (IPH; β = 8.4%, 95% CI: 4.5 to 12.7%), less late IPH (β = - 8.2%, 95% CI: - 11.3 to - 5.4), and fewer fibrous cap disruptions (45% vs. 67%, p = 0.061). Chinese plaques were more homogeneous and had a higher percentage of plaques with features of xanthomas than did US plaques (20% vs 2.7%, p < 0.001).

conclusionsThe histology of Chinese plaques differs significantly from that of U.S. plaques, suggesting substantial differences in the pathophysiology of atherosclerotic cerebrovascular disease between Chinese and North American populations, which indicates a need for a different management approach.

Indexed as

Atherosclerotic plaquesCarotid arteryCarotid endarterectomyHistology

Identifiers

PMID41068949
PMCPMC12509396

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