ArticleJournal of translational medicine2025
Conjunctival and retinal microvascular loss in systemic lupus erythematosus: a swept-source OCTA study.
Article in Journal of translational medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Investigation of the association between retinal microcirculation and renal function in children with lupus nephritis.Clinical rheumatology · 2026Article
- Topology-preserving, diameter-specific framework for conjunctival vessel segmentation and tortuosity analysis in diabetes.Scientific reports · 2026Article
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Authors and funding
5 authors.
Funding
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Abstract
purposeThis study aimed to characterize conjunctival and retinal microvascular alterations in Systemic lupus erythematosus (SLE) using swept-source optical coherence tomography angiography (SS-OCTA), and to evaluate their correlation with systemic clinical manifestations.
methodsThis cross-sectional study enrolled 32 SLE patients and 32 age, sex, and spherical equivalent matched controls. Participants underwent swept-source OCTA imaging of nasal and temporal conjunctiva (16 × 12 mm scans) and macula (6 × 6 mm scans). Vessel density of conjunctival vessel, superficial vascular plexus (SVP), and deep vascular plexus (DVP) were quantified using automated segmentation. Correlation analyses were conducted to evaluate the association between conjunctival and retinal vascular densities, as well as their relationships with clinical parameters of systemic involvement and disease activity.
resultsSLE patients showed significant reductions in nasal (45.0% vs. 60.1%, p < 0.001) and temporal (51.8% vs. 60.5%, p = 0.009) conjunctival vascular density, alongside pan-retinal DVP attenuation (p < 0.05). Combined nasal conjunctival and retinal nasal DVP analysis yielded high diagnostic accuracy (AUC 0.897). Microvascular loss was independent of organ involvement or disease activity (p > 0.05).
conclusionsSLE is associated with significant reductions in conjunctival and retinal DVP vascular density. Combined multimodal SS-OCTA analysis achieved superior diagnostic accuracy, with microvascular loss independent of disease activity or organ-specific involvement, suggesting systemic microvascular injury as a unifying SLE feature. Conjunctival-retinal vascular metrics may serve as potential new biomarkers for SLE.
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