ArticleJournal of nanobiotechnology2025
Hybrid metallic nanozyme with nitric oxide-releasing photothermal coating for accelerated infected diabetic wound healing.
Article in Journal of nanobiotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- Ultrasound-activated piezoelectric Bi@Bi-MOF enables STING-mediated immunotherapy for implant-associated infections.Journal of nanobiotechnology · 2026Article
- Stimuli-Responsive Nanomaterial-Based Biosensor Structures for Wound Care: pH, ROS, and Temperature Sensing Strategies.Micromachines · 2026Review
- Biofilm Control with Rare-Earth Oxides: A Mechanistic Framework for Next-Generation Antibiofilm Materials.Nanomaterials (Basel, Switzerland) · 2026Review
- Exploration of recent advancements of nanoparticle-based therapeutics emphasis on diabetic-related chronic wound management: a comprehensive review.Archives of pharmacal research · 2026Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Infected diabetic wounds are prone to developing bacterial biofilms and are difficult to treat due to a lack of strategies that can eliminate drug-resistant bacteria. Conventional antibiotics can't achieve the desired antibacterial effect due to their limited penetration into the biofilm, which makes the treatment challenging. In this study, we developed NIR-responsive nitric oxide (NO) releasing Ce: Zn nanoflowers (PDA@SNP@Ce:Zn NFs) to combat the drug-resistant bacteria by the synergistic antibacterial effect of metal ions and photothermal effect. PDA@SNP@Ce:Zn NFs exhibited significant antibacterial and antibiofilm effects against Methicillin-resistant Staphylococcus aureus (MRSA) and Staphylococcus aureus (SA). The nanoflowers exhibited significant inhibitory effects on the virulence of MRSA and SA, including spreading motility, secretion of phenol-soluble modulin proteins, and staphyloxanthin, after laser irradiation. The PDA@SNP@Ce:Zn NFs were able to cause membrane disruption and eradicate the MRSA and SA biofilms that were analyzed by scanning electron microscope. Additionally, these nanoflowers significantly accelerated wound healing in MRSA-infected diabetic rats by reducing the inflammation and promoting angiogenesis at the wound site. Our findings suggested that the developed photothermal nanoflower system would be an alternate approach to prevent drug-resistant bacterial infections.
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Registered trials
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