Evidence map›Paper›PMID 41068911›Full record

ArticleHead & face medicine2025

Novel approach to orbital hard- and soft-tissue symmetry analysis: a pilot validation.

Ilya Tsiklin, Joeri Meyns, Robin Willaert, Thanatchaporn Jindanil, Nermin Morgan, Flavia Preda, Eman Shaheen, Reinhilde Jacobs

Abstract readValidation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Head & face medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ilya TsiklinOMFS IMPATH Research Group, Department of Imaging and Pathology, Faculty of Medicine, University of Leuven, Kapucijnenvoer 33, Leuven, 3000, Belgium. ilyatsiklin@gmail.com.
Joeri MeynsOMFS IMPATH Research Group, Department of Imaging and Pathology, Faculty of Medicine, University of Leuven, Kapucijnenvoer 33, Leuven, 3000, Belgium.
Robin WillaertOMFS IMPATH Research Group, Department of Imaging and Pathology, Faculty of Medicine, University of Leuven, Kapucijnenvoer 33, Leuven, 3000, Belgium.
Thanatchaporn JindanilOMFS IMPATH Research Group, Department of Imaging and Pathology, Faculty of Medicine, University of Leuven, Kapucijnenvoer 33, Leuven, 3000, Belgium.
Nermin MorganDepartment of Oral and Maxillofacial Surgery, University Hospitals Leuven, Leuven, Belgium.
Flavia PredaDepartment of Oral and Maxillofacial Surgery, University Hospitals Leuven, Leuven, Belgium.
Eman ShaheenDepartment of Oral and Maxillofacial Surgery, University Hospitals Leuven, Leuven, Belgium.
Reinhilde JacobsOMFS IMPATH Research Group, Department of Imaging and Pathology, Faculty of Medicine, University of Leuven, Kapucijnenvoer 33, Leuven, 3000, Belgium.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundVolume-based orbital symmetry analysis can hardly explain a particular orbital structure’s involvement and contribution to asymmetry. This study aimed to validate a novel approach to orbital surface-based hard- and soft-tissue symmetry analysis, providing comprehensible and clinically applicable interpretation. CT-based segmentation of the orbital hard- and soft-tissue structures was followed by model mirroring, global registration, and surface-based symmetry analysis, with both qualitative and quantitative interpretations in twenty young, healthy subjects.

resultsThe entire soft-tissue model’s global symmetry was higher compared to the entire hard-tissue volume (p = 0.027), reflecting the potential of the soft tissue to compensate for bone-structure asymmetry. No significant difference in symmetry parameters was found for particular orbital walls (p = 0.803) and intra-orbital soft-tissue structures (p = 0.256). The strong negative correlation between relative global and local symmetry parameters and absolute root mean square (RMS) distance values demonstrates the reliability of the suggested novel approach. Correlations between orbital walls symmetry parameters were higher compared to soft-tissue orbital structures.

conclusionAside from the accurate RMS distance calculation, the global and local symmetry analysis presented in this pilot study offers valuable, reliable, and comprehensible information on the contribution of particular orbital hard- and soft-tissue structures to facial symmetry.

Indexed as

OrbitTomography, X-Ray ComputedAdultFemaleHumansImaging, Three-DimensionalMalePilot ProjectsReproducibility of ResultsYoung AdultHard- and soft-tissue structuresModel mirroring and registrationOrbital symmetrySurface-based symmetry analysis

Identifiers

PMID41068911
PMCPMC12512270

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.