ArticleBMC endocrine disorders2025
Classification of and risk factors for sodium imbalance developing after transsphenoidal surgery for pituitary neuroendocrine tumors.
Article in BMC endocrine disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Preoperative electrolyte-based metabolic biomarkers for prognostic assessment in gastric cancer: a multicenter study.Frontiers in endocrinology · 2026Article
- Targeting lineage-specific heterogeneity and hypovascular-fibrotic barriers may enable precision immunotherapy in pituitary neuroendocrine tumors.Frontiers in immunology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeSodium imbalance are common complications after transsphenoidal surgery (TSS) for pituitary neuroendocrine tumors (PitNETs). We characterized the types of sodium imbalance, identified risk factors for these disorders, and provided corresponding treatment advice.
methodsWe screened patients who had undergone TSS for PitNETs at a single center to identify those who did and did not (control) develop sodium imbalance. Disorders were classified using three groups, based mainly on the serum sodium level and degree of daily increase or decrease therein. We performed multivariable logistic regression analysis to identify risk factors among numerous variables (patient characteristics, third ventricle deformation, tumor volume, maximum tumor diameter, hydrocephalus, cerebrospinal fluid rhinorrhea, and pituitary target gland axes).
resultsThe sample comprised 105 patients with and 129 patients without sodium imbalance. Logistic regression analysis showed that hydrocephalus [P = 0.0015, odds ratio (OR) = 7.112, 95% confidence interval (CI) 1.475-34.3], cerebrospinal fluid rhinorrhea (P < 0.001, OR = 4.62, 95% CI 2.372-9), and preoperative hypothalamus-pituitary-gonadal (HPG) axis hypofunction (P = 0.009, OR = 3.211, 95% CI 1.341-7.691) were independent risk factors sodium imbalance development after TSS. Compared with the control, risk factors differed among disorder groups.
conclusionThis study showed that cerebrospinal fluid rhinorrhea, hydrocephalus, and preoperative HPG axis hypofunction are risk factors for sodium imbalance development after TSS for PitNETs. We divided sodium imbalances into three groups to guide treatment.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.