Evidence map›Paper›PMID 41068719›Full record

SynthesisBMC gastroenterology2025

Early oral feeding after laparoscopic total gastrectomy in gastric cancer patients: a meta-analysis of randomized controlled trials and cohort studies.

Leila Mohajeri, Reza Daghayeghi, Navid Rostami, Yasamin Moeinipour, Reza Hossein Zadeh, Raoul Hossein Zadeh, Reza Shah Hosseini, Mohsen Jabbari, Komeil Aghazadeh Habashi, Niloofar Deravi

Abstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BMC gastroenterology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Leila Mohajeri *Faculty of Medicine, Tabriz Branch, Islamic Azad University, Tabriz, Iran.
Reza Daghayeghi *Institute of Fundamental Medicine and Biology, Kazan Federal University, Kazan, Russia.
Navid Rostami *School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Yasamin MoeinipourCardiovascular Surgery, Cardiothoracic Surgery Division, Cardiothoracic Surgery Department, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Reza Hossein ZadehStudent Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Raoul Hossein ZadehCardiovascular Surgery, Cardiothoracic Surgery Division, Cardiothoracic Surgery Department, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Reza Shah HosseiniFaculty of medicine, Istanbul Medipol University, Istanbul, Turkey.
Mohsen JabbariTaleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Komeil Aghazadeh HabashiStudents research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
Niloofar DeraviStudents research Committee, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Niloofarderavi@yahoo.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGastric cancer remains a leading cause of cancer-related morbidity and mortality worldwide, with surgery being central to treatment. However, postoperative malnutrition is common and significantly impairs recovery. Early oral feeding (EOF) has been proposed as a strategy to promote gastrointestinal recovery and reduce complications, but its clinical effectiveness following gastrectomy remains uncertain.

methodsA systematic review and meta-analysis were conducted according to PRISMA guidelines. Studies comparing EOF with delayed oral feeding (TOF) in gastric cancer patients were included. Outcomes assessed were hospital stay, time to first anal exhaust, postoperative complications, feeding tolerance, and serum albumin and prealbumin levels. Data were pooled using random-effects models, and evidence certainty was evaluated using the GRADE approach.

resultsFifteen studies (1,847 patients) were included. EOF significantly reduced hospital stay (-1.82 days) and time to first anal exhaust (-0.85 days), and improved albumin and prealbumin levels. No significant differences were found in postoperative complications or feeding intolerance. Subgroup analyses demonstrated consistent findings across surgical techniques, extent of gastrectomy, ERAS protocol implementation, and study design. Overall, the certainty of evidence was rated as very low due to concerns regarding risk of bias, heterogeneity, and imprecision.

conclusionEOF is a safe and effective approach after gastrectomy, promoting faster recovery without increasing complications. Further trials are needed to confirm its benefits and guide standardized protocols.

Indexed as

Enteral NutritionGastrectomyLaparoscopyPostoperative CareStomach NeoplasmsCohort StudiesHumansLength of StayMalnutritionPostoperative ComplicationsRandomized Controlled Trials as TopicTime FactorsEarly oral feedingGastrectomyGastric cancerMeta-analysisPostoperative care

Identifiers

PMID41068719
PMCPMC12512641

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.