Evidence map›Paper›PMID 41068688›Full record

ArticleBMC cancer2025

Distinct genomic subgroups and mutational patterns in undifferentiated/dedifferentiated endometrial carcinoma.

Chen-Yang Huang, Angel Chao, Chiao-Yun Lin, Steven G Rozen, An-Shine Chao, Chen-Bin Chang, Hsiu-Jung Tung, Ren-Chin Wu, Chyong-Huey Lai

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Chen-Yang HuangDepartment of Medical Oncology and Genome Medicine Core Laboratory, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan.
Angel ChaoDepartment of Obstetrics and Gynecology, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan. drangiechao@gmail.com.ORCID http://orcid.org/0000-0003-3834-2754
Chiao-Yun LinGynecologic Cancer Research Center, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan.
Steven G RozenDepartment of Biostatistics and Bioinformatics, Duke University School of Medicine, Durham, NC, USA.
An-Shine ChaoDepartment of Obstetrics and Gynecology, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan.
Chen-Bin ChangDepartment of Obstetrics and Gynecology, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan.
Hsiu-Jung TungDepartment of Obstetrics and Gynecology, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan.
Ren-Chin WuGynecologic Cancer Research Center, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan. renchin.wu@gmail.com.ORCID http://orcid.org/0000-0003-1439-0874
Chyong-Huey LaiDepartment of Obstetrics and Gynecology, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan. sh46erry@ms6.hinet.net.ORCID http://orcid.org/0000-0002-9977-9645

Funding

Chang Gung Memorial Hospital, Linkou CORPG3P0201National Science and Technology Council 113-2314-B-182A-108-MY3
6 · The paper itself

Abstract

backgroundEndometrial cancer represents a significant global health challenge, with undifferentiated and dedifferentiated endometrial carcinoma (UDEC) being a particularly aggressive subset.

methodsWe employed whole-exome sequencing (WES) to comprehensively characterize the molecular landscape of 29 UDECs in a single institution cohort. We analyzed driver mutations, molecular subgroups, SWI/SNF complex, DNA mismatch repair (MMR) pathways, and somatic copy number alterations (SCNAs).

resultsWe identified 5 (17%) ultramutated tumors, 14 (48%) DNA mismatch repair (MMR)-deficient tumors, and 10 (35%) mutation-low tumors in this cohort. Mutations in the SWI/SNF family and other driver genes are common, including PTEN, ARID1A, KMT2B, ARID1B, SMARCA4, and PIK3CA. Genomic inactivation of SWI/SNF complex genes occurred in 19 of 29 (66%) of cases, highlighting the frequent chromatin remodeling dysfunction in UDEC. We observed frequent homopolymer mutations in UDECs with MMR deficiency, with RPL22

conclusionsOur analysis revealed distinct architectures and actionable alterations in UDEC. The identification of molecular subgroups provides a promising framework for prognostic stratification. Collectively, our findings not only advance our understanding of UDEC biology but also illuminate potential translational applications.

Indexed as

Endometrial NeoplasmsMutationAdultAgedAged, 80 and overDNA-Binding ProteinsDNA Copy Number VariationsDNA Mismatch RepairExome SequencingFemaleGenomicsHumansMiddle AgedPrognosisTranscription FactorsARID1A protein, humanDNA-Binding ProteinsTranscription FactorsMismatch repair deficiencyMutational signaturesUndifferentiated and dedifferentiated endometrial carcinomaWhole-exome sequencing

Identifiers

PMID41068688
PMCPMC12512612

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.