ArticleBMC gastroenterology2025
Clinical features, treatments and prognosis of COVID-19 (Omicron) and hemorrhagic colitis: a case series study.
Article in BMC gastroenterology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundThis study aims to evaluate the gastrointestinal implications of the Omicron variant, focusing on intestinal injury.
methodsThis retrospective, single-center study analyzed a case series of 12 Omicron patients with hemorrhagic colitis at the First Hospital of Yangtze University in December 2022.
resultsThe study involved 12 Omicron patients with hemorrhagic colitis, aged 52 to 72 years. The primary clinical symptoms included abdominal pain and hematochezia. Laboratory findings in some patients showed decreased hemoglobin, elevated D-dimer, and increased C-reactive protein levels. Abdominal CT demonstrated intestinal wall thickening and exudation. Colonoscopy revealed intestinal damage characterized by varying degrees of erythema, erosion, and ulceration. The most common site of lesions was the sigmoid colon, followed by the transverse colon and descending colon. Histopathological examination revealed a decrease in the glands within the lamina propria of the intestinal mucosa, along with focal infiltration of neutrophils or lymphocytes and interstitial hemorrhage. Following the treatment, 11 patients improved significantly, while one patient died from multiple organ dysfunction syndrome (MODS), secondary to severe COVID-19 pneumonia.
conclusionThe Omicron may be associated with intestinal injury. Most patients could recover after receiving conservative treatment.
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