Evidence map›Paper›PMID 41068664›Full record

Observational studyBMC gastroenterology2025

Chronic PPI use after anti-reflux surgery: a retrospective observational pilot study.

J W Van Dam, L M Van den Dop, G Van den Brink, M W M De Waal, J C Kiefte-de Jong, M E Numans, W E Hueting

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in BMC gastroenterology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

J W Van DamDepartment of Public Health and Primary Care/Health Campus Den Haag, Leiden University Medical Center, PO BOX 9600, 2300 RC, Hippocratespad 21, Leiden, 2333 ZD, The Netherlands. joepvandam@live.nl.ORCID http://orcid.org/0009-0000-3080-7014
L M Van den DopDepartment of Public Health and Primary Care/Health Campus Den Haag, Leiden University Medical Center, PO BOX 9600, 2300 RC, Hippocratespad 21, Leiden, 2333 ZD, The Netherlands.
G Van den BrinkDepartment of Public Health and Primary Care/Health Campus Den Haag, Leiden University Medical Center, PO BOX 9600, 2300 RC, Hippocratespad 21, Leiden, 2333 ZD, The Netherlands.
M W M De WaalDepartment of Public Health and Primary Care/Health Campus Den Haag, Leiden University Medical Center, PO BOX 9600, 2300 RC, Hippocratespad 21, Leiden, 2333 ZD, The Netherlands.
J C Kiefte-de JongDepartment of Public Health and Primary Care/Health Campus Den Haag, Leiden University Medical Center, PO BOX 9600, 2300 RC, Hippocratespad 21, Leiden, 2333 ZD, The Netherlands.
M E NumansDepartment of Public Health and Primary Care/Health Campus Den Haag, Leiden University Medical Center, PO BOX 9600, 2300 RC, Hippocratespad 21, Leiden, 2333 ZD, The Netherlands.
W E HuetingDepartment of Public Health and Primary Care/Health Campus Den Haag, Leiden University Medical Center, PO BOX 9600, 2300 RC, Hippocratespad 21, Leiden, 2333 ZD, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundChronic Proton Pump Inhibitor (PPI) use after anti-reflux surgery (ARS) remains common. Which patient factors contribute to chronic PPI use after surgery is unclear. The primary aim was to provide a long-term outcome of ARS by evaluating PPI use in the years after surgery and identify determinants of chronic PPI use after surgery.

methodsPatients aged ≥ 18 years who underwent ARS between 2011 and 2020 in a single referral center were eligible. Patient data were retrospectively assessed by medical record review. PPI data were acquired from primary care pharmacies. Chronic PPI use was defined as ≥ 180 Defined Daily Doses (DDD) per year. Patient characteristics predisposing chronic PPI use were identified. Statistical analysis included descriptive statistics and multivariable logistic regressions and a Kaplan-Meier curve.

resultsOnly 45 out of 364 eligible patients (12%) had complete data for analysis. Chronic PPI use was present in 79.5% before surgery compared to 29.5% at 1 and 2 years and 32.0% for 5 years after surgery. A median difference in PPI use of -257 DDD was found for the year after surgery compared to the year before surgery. Male gender was associated with chronic PPI use after surgery but no other determinants were found.

conclusionApproximately a third of the patients use PPIs up to 5 years after surgery. Although ARS is recommended when PPI treatment fails or to avert lifelong PPI use, quality of life and PPI use may not correlate linearly. Adequate patient selection and expectation management before surgery is paramount.

Indexed as

Gastroesophageal RefluxProton Pump InhibitorsAdultAgedFemaleHumansMaleMiddle AgedPilot ProjectsRetrospective StudiesSex FactorsProton Pump InhibitorsAnti-reflux surgeryFundoplicationGERDPPI

Identifiers

PMID41068664
PMCPMC12512783

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.