Evidence map›Paper›PMID 41068637›Full record

ArticleBMC gastroenterology2025

The role of peripheral blood cell analysis-derived inflammatory parameters in predicting malignant duodenal stenosis.

Palidanguli Pata'er, Shanshan Liu, Jiawei Chen, Qi He, Guochen Shang, Yu Jin, Jun Liu, Chaoqun Han, Shi Liu

Abstract read
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In one paragraph

Article in BMC gastroenterology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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5 · Who and what money

Authors and funding

9 authors.

Palidanguli Pata'er *Division of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, 430022, Wuhan, China.
Shanshan Liu *Division of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, 430022, Wuhan, China.
Jiawei ChenDivision of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, 430022, Wuhan, China.
Qi HeDivision of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, 430022, Wuhan, China.
Guochen ShangDivision of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, 430022, Wuhan, China.
Yu JinDivision of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, 430022, Wuhan, China.
Jun LiuDivision of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, 430022, Wuhan, China.
Chaoqun HanDivision of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, 430022, Wuhan, China. hcq1987912@hotmail.com.
Shi LiuDivision of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, 430022, Wuhan, China. 13370383967@163.com.

Funding

This study was supported in part by the National Natural Science Foundation of China No. 82170570, 82270698, 82270583
6 · The paper itself

Abstract

backgroundThe unique location and complex anatomical structure of the duodenum poses challenges for the application of endoscopic biopsy. Differentiating benign and malignant duodenal stenosis remains difficult for clinicians. Therefore, there is an urgent need for a new, reliable, and cost-effective biomarker to differentiate between benign and malignant duodenal stenosis.

methods140 patients diagnosed with duodenal stenosis during endoscopic examinations and subsequently underwent biopsies or surgery for pathological analysis were enrolled in the study. Based on the pathological results, patients were classified into benign duodenal stenosis group and malignant duodenal stenosis group. Clinical data and results of the initial peripheral blood analysis were collected retrospectively and analyzed.

resultsCompared to patients with benign duodenal stenosis, patients with malignant duodenal stenosis exhibited higher neutrophil-to-lymphocyte ratio (NLR, P < 0.001), platelet-to-lymphocyte ratio (PLR, P < 0.001), and lower lymphocyte-to-monocyte ratio (LMR, P < 0.001). Moreover, an increase in age, NLR, and AST were found to be independent risk factors for malignant duodenal stenosis. Besides, NLR > 3.42 was a more dependable predictor of malignant duodenal stenosis, with a sensitivity of 80.3% and a specificity of 91.1%.

conclusionsPeripheral blood cells analysis derived inflammatory biomarkers such as NLR holds significant predictive value for malignant duodenal stenosis.

Indexed as

Duodenal NeoplasmsDuodenal ObstructionAdultAgedAged, 80 and overBiomarkersBlood PlateletsDiagnosis, DifferentialFemaleHumansLymphocyte CountLymphocytesMaleMiddle AgedMonocytesNeutrophilsBiomarkersDuodenal stenosisLymphocyte-to-monocyte ratioNeutrophil-to-lymphocyte ratioPeripheral blood cells analysisPlatelet-to-lymphocyte ratio

Identifiers

PMID41068637
PMCPMC12512693

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.