Evidence map›Paper›PMID 41068626›Full record

ArticleBMC infectious diseases2025

Clinical characteristics and prognostic factors analysis in patients with post-neurosurgical intracranial infection caused by Acinetobacter baumannii.

Bingxin Tian, Huangmin Bao, Xin Yang, Runli Yu, Min Lyu, Wen Liu, Xiaoya Huang, Qin Ding

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Bingxin Tian *Department of Infectious Disease and Hepatic Disease, The Affiliated Hospital of Xuzhou Medical University, No. 9 Kunpeng North Road, Xuzhou, Jiangsu Province, 221006, China.
Huangmin Bao *The First Clinical College of Xuzhou Medical University, Xuzhou, Jiangsu Province, China.
Xin YangDepartment of Infectious Disease and Hepatic Disease, The Affiliated Hospital of Xuzhou Medical University, No. 9 Kunpeng North Road, Xuzhou, Jiangsu Province, 221006, China.
Runli YuDepartment of Infectious Disease and Hepatic Disease, The Affiliated Hospital of Xuzhou Medical University, No. 9 Kunpeng North Road, Xuzhou, Jiangsu Province, 221006, China.
Min LyuDepartment of Infectious Disease and Hepatic Disease, The Affiliated Hospital of Xuzhou Medical University, No. 9 Kunpeng North Road, Xuzhou, Jiangsu Province, 221006, China.
Wen LiuDepartment of Infectious Disease and Hepatic Disease, The Affiliated Hospital of Xuzhou Medical University, No. 9 Kunpeng North Road, Xuzhou, Jiangsu Province, 221006, China.
Xiaoya HuangDepartment of Infectious Disease and Hepatic Disease, The Affiliated Hospital of Xuzhou Medical University, No. 9 Kunpeng North Road, Xuzhou, Jiangsu Province, 221006, China.
Qin DingDepartment of Infectious Disease and Hepatic Disease, The Affiliated Hospital of Xuzhou Medical University, No. 9 Kunpeng North Road, Xuzhou, Jiangsu Province, 221006, China. kgylan163@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAcinetobacter baumannii intracranial infection is a significant problem affecting the prognosis of neurosurgical patients. This study aimed to analyze the clinical characteristics and identify prognostic factors for in-hospital mortality in patients with post-neurosurgical A. baumannii intracranial infections.

methodsWe retrospectively analyzed clinical data from 109 patients diagnosed with A. baumannii intracranial infection following neurosurgery between January 2015 and December 2022. A nomogram predicting in-hospital mortality was developed using logistic regression and validated through receiver operating characteristic(ROC) analysis.

resultsA total of 109 patients were included in this study, with an in-hospital mortality rate of 58.7%. Among the A. baumannii strains isolated from cerebrospinal fluid(CSF) cultures, 95.4% exhibited carbapenem resistance. Multivariate analysis identified CSF protein level (OR = 1.132, 95% CI = 1.039–1.233), A. baumannii bloodstream infection (OR = 8.9, 95% CI = 1.536–51.559), length of stay(OR = 0.946, 95% CI = 0.919–0.974), sex(male)(OR = 0.263, 95% CI = 0.077–0.894), platelet count (OR = 0.996, 95% CI = 0.992–0.999), and albumin level (OR = 0.896, 95% CI = 0.818–0.982) as independent factors associated with in-hospital mortality. A nomogram incorporating these factors achieved an area under the curve(AUC) of 0.879 (95% CI = 0.806–0.952).

conclusionPost-neurosurgical intracranial infection with A. baumannii is associated with a high in-hospital mortality rate. Our study identified several independent prognostic factors, including CSF protein level, A. baumannii bloodstream infection, length of stay, sex(male), platelet count, and albumin level. These findings highlight the need for early identification and targeted interventions to improve patient outcomes.

Indexed as

Acinetobacter baumanniiAcinetobacter InfectionsNeurosurgical ProceduresAdultAgedAnti-Bacterial AgentsFemaleHospital MortalityHumansMaleMiddle AgedNomogramsPrognosisRetrospective StudiesRisk FactorsROC CurveAnti-Bacterial AgentsAcinetobacter baumanniiAntimicrobial resistanceIntracranial infectionPrognosis

Identifiers

PMID41068626
PMCPMC12512837

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.