Evidence map›Paper›PMID 41068573›Full record

ArticleBMC genomics2025

The genetic influence of sex on gene expression for blood in pigs.

Qing Lin, Junxiong Huang, Tianru Zhou, Teddy Tinashe Chitotombe, Jinyan Teng, Jiaqi Li

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Article in BMC genomics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Qing LinState Key Laboratory of Swine and Poultry Breeding Industry, Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, College of Animal Science, South China Agricultural University, Guangzhou, 510642, China.
Junxiong HuangState Key Laboratory of Swine and Poultry Breeding Industry, Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, College of Animal Science, South China Agricultural University, Guangzhou, 510642, China.
Tianru ZhouState Key Laboratory of Swine and Poultry Breeding Industry, Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, College of Animal Science, South China Agricultural University, Guangzhou, 510642, China.
Teddy Tinashe ChitotombeState Key Laboratory of Swine and Poultry Breeding Industry, Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, College of Animal Science, South China Agricultural University, Guangzhou, 510642, China.
Jinyan TengState Key Laboratory of Swine and Poultry Breeding Industry, Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, College of Animal Science, South China Agricultural University, Guangzhou, 510642, China.
Jiaqi LiState Key Laboratory of Swine and Poultry Breeding Industry, Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, College of Animal Science, South China Agricultural University, Guangzhou, 510642, China. jqli@scau.edu.cn.

Funding

the earmarked fund for China Agriculture Research System CARS-35the fundings from National Key R&D Program of China 2022YFF1000900
6 · The paper itself

Abstract

backgroundPigs are one of the most important farm animals in the agrifood industry. Many complex traits and patterns of gene expression exhibit sexual dimorphisms in pigs. However, the impact of sex on gene expression remains poorly understood.

resultsIn this study, we utilized the gene expression data of blood tissue derived from PigGTEx project to explore the genetic influence of sex on gene expression in pigs. Differential gene expression analysis identified 116 male-biased and 248 female-biased genes. Sex-combined and sex-stratified cis-heritability (cis-h

conclusionsThis study revealed sex-biased gene expression patterns and sex-dependent regulatory effect of gene expression of blood tissues in pigs. Additionally, this study found the sexually dimorphic regulation of gene expression underlying complex traits. These findings provided a comprehensive insight and resource and advance our understanding of sexual dimorphism in genetic mechanism underlying complex traits in blood.

Indexed as

Gene Expression RegulationSex CharacteristicsAnimalsFemaleGene Expression ProfilingMaleQuantitative Trait LociSex FactorsSwineBloodExpression quantitative trait locusGene expressionPigSex-biased gene

Identifiers

PMID41068573
PMCPMC12512681

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.