Evidence map›Paper›PMID 41068571›Full record

ArticleBMC genomics2025

A genome-wide investigation of insidious uveitis in Appaloosa horses.

N B Kingsley, L Sandmeyer, A Dwyer, C D Langefeld, R J McMullen, M McCue, M Lassaline, R R Bellone

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC genomics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

8 authors.

N B KingsleyVeterinary Genetics Laboratory, School of Veterinary Medicine, University of California - Davis, Davis, CA, 95616, USA.
L SandmeyerDepartment of Small Animal Clinical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Saskatchewan , S7N 5B4, Canada.
A DwyerGenesee Valley Equine Clinic, LLC, Scottsville, NY, 14546, USA.
C D LangefeldDepartment of Biostatistics and Data Science, Division of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, NC, 27101, USA.
R J McMullenEquine Department, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland.
M McCueVeterinary Population Medicine Department, College of Veterinary Medicine, University of Minnesota, St. Paul, MN, 55108, USA.
M LassalineSchool of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
R R BelloneVeterinary Genetics Laboratory, School of Veterinary Medicine, University of California - Davis, Davis, CA, 95616, USA. rbellone@ucdavis.edu.

Funding

Center for Equine Health 22-JMorris Animal Foundation D16EQ-028
6 · The paper itself

Abstract

backgroundEquine recurrent uveitis (ERU), an inflammatory eye disease, is the leading cause of blindness among horses. Insidious uveitis, a form of ERU, is especially pervasive within the Appaloosa breed and is highly heritable (h

resultsA genome-wide association study (GWAS) using relatedness, LP genotype, sex, and age as covariates was performed on a sample of 96 Appaloosas (36 cases and 60 controls) and identified a 9.7 Kb region of association on ECA X (chrX:14528106-14537812) as significantly associated (P = 2.11 × 10

conclusionIn addition to the LP locus, our investigation identified a locus on chromosome X with a significant association to insidious uveitis in Appaloosas. Replication testing in an independent cohort is necessary to determine if this locus is indeed a causal risk locus.

Indexed as

Genome-Wide Association StudyHorse DiseasesUveitisAnimalsFemaleGenetic Predisposition to DiseaseGenotypeHorsesMalePolymorphism, Single NucleotideEquineERUGWASInflammationMoon blindnessPanuveitisPeriodic ophthalmia

Identifiers

PMID41068571
PMCPMC12513139

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.