Evidence map›Paper›PMID 41068562›Full record

ArticleBMC ecology and evolution2025

An Orco dependent pathway suppresses egg-laying attraction to ripe fruit volatile compounds in Drosophila melanogaster but not in D. suzukii.

Sebastien Lebreton, K P Siju, Matthieu Cavey, Caroline Minervino, Maïlys Delcroix, Xavier Fernandez, Thomas Michel, Ilona C Grunwald Kadow, Benjamin Prud'homme

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC ecology and evolution, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Sebastien LebretonAix-Marseille Université, CNRS, IBDM, Institut de Biologie du Développement de Marseille, Campus de Luminy Case 907, 13288 Marseille Cedex 9, Marseille, France.
K P SijuTechnical University of Munich, School of Life Sciences, Liesel-Beckmann-Str. 4, Freising, 85354, Germany.
Matthieu CaveyAix-Marseille Université, CNRS, IBDM, Institut de Biologie du Développement de Marseille, Campus de Luminy Case 907, 13288 Marseille Cedex 9, Marseille, France.
Caroline MinervinoAix-Marseille Université, CNRS, IBDM, Institut de Biologie du Développement de Marseille, Campus de Luminy Case 907, 13288 Marseille Cedex 9, Marseille, France.
Maïlys DelcroixUniversité Côte d'Azur, CNRS, Institut de Chimie de Nice, UMR 7272, Nice, 06000, France.
Xavier FernandezUniversité Côte d'Azur, CNRS, Institut de Chimie de Nice, UMR 7272, Nice, 06000, France.
Thomas MichelUniversité Côte d'Azur, CNRS, Institut de Chimie de Nice, UMR 7272, Nice, 06000, France.
Ilona C Grunwald KadowTechnical University of Munich, School of Life Sciences, Liesel-Beckmann-Str. 4, Freising, 85354, Germany.
Benjamin Prud'hommeAix-Marseille Université, CNRS, IBDM, Institut de Biologie du Développement de Marseille, Campus de Luminy Case 907, 13288 Marseille Cedex 9, Marseille, France. benjamin.prudhomme@univ-amu.fr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMost Drosophila species lay their eggs on a wide range of overripe or rotting fruits. By contrast, D. suzukii has evolved a strong preference for undamaged ripe fruits, a shift that has made it one of the most important pests of small fruits worldwide. Growing evidence suggests that this host preference shift is linked to modifications in the fly's olfactory system. Unlike D. melanogaster, D. suzukii is attracted by ripe strawberry volatile compounds for oviposition.

resultsIn this study, we investigated the mechanisms underlying this behavioral divergence. We identified two strawberry volatiles, hexanoic acid and methyl butyrate, that, together recapitulate the species-specific oviposition preferences. D. suzukii is attracted by this two-component blend, whereas in D. melanogaster attraction to this blend is suppressed by an OR-dependent mechanism. In vivo calcium imaging of the antennal lobes revealed that the perception of these compounds is largely conserved between species, with only subtle differences. This suggests that the divergence in the olfactory perception of this two-component blend arises downstream of sensory neuron activity, within higher levels of olfactory processing.

conclusionsTaken together, our results suggest that D. melanogaster has evolved an as-yet unidentified mechanism for integrating olfactory signals that suppresses attraction to unsuitable oviposition substrates when multiple key volatile are detected simultaneously.

Indexed as

DrosophilaDrosophila melanogasterDrosophila ProteinsFruitOvipositionReceptors, OdorantVolatile Organic CompoundsAnimalsButyratesCaproatesFemaleFragariaSpecies SpecificityButyratesCaproatesDrosophila Proteinshexanoic acidOrco protein, DrosophilaReceptors, OdorantVolatile Organic CompoundsAntennal lobesBehaviorDrosophilaEgg-laying preferenceEvolutionFruit volatile compoundsOdorant receptorsOlfaction

Identifiers

PMID41068562
PMCPMC12512289

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.