Evidence map›Paper›PMID 41068550›Full record

ReviewJournal of assisted reproduction and genetics2025

The impact of chemical pollution and warming on male fertility: a narrative review by the Special Interest Group "Environment and Fertility" of the Italian Society of Fertility and Sterility and Reproductive Medicine (SIFES-MR).

Giuseppe Defeudis, Cristina de Angelis, Rossella Mazzilli, Federica Barbagallo, Claudia Leanza, Iva Sabovic, Rosita A Condorelli, Rocco Rago, Daniele Gianfrilli, Rosario Pivonello and 4 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of assisted reproduction and genetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Giuseppe DefeudisDepartment of Theoretical and Applied Sciences, eCampus University, Novedrate CO, Italy.
Cristina de AngelisDipartimento di Medicina Clinica e Chirurgia, Sezione di Endocrinologia, Diabetologia, Andrologia e Nutrizione, Unità di Andrologia e Medicina della Riproduzione, Sessualità e Affermazione di Genere, Università Federico II di Napoli, Naples, Italy.
Rossella MazzilliDepartment of Clinical and Molecular Medicine, Sapienza University of Rome, Rome, Italy.
Federica BarbagalloDepartment of Clinical and Experimental Medicine, University of Catania, Catania, Italy.
Claudia LeanzaDepartment of Clinical and Experimental Medicine, University of Catania, Catania, Italy.
Iva SabovicUnit of Andrology and Medicine of Human Reproduction, Department of Medicine - DIMED, University of Padova, Via Giustiniani, 2, Padua, 35128, Italy.
Rosita A CondorelliDepartment of Clinical and Experimental Medicine, University of Catania, Catania, Italy.
Rocco RagoPhysiopathology of Reproduction and Andrology Unit, Sandro Pertini Hospital, Rome, Italy.
Daniele GianfrilliDepartment of Experimental Medicine, University Sapienza of Rome, Rome, Italy.
Rosario PivonelloDipartimento di Medicina Clinica e Chirurgia, Sezione di Endocrinologia, Diabetologia, Andrologia e Nutrizione, Unità di Andrologia e Medicina della Riproduzione, Sessualità e Affermazione di Genere, Università Federico II di Napoli, Naples, Italy.
Andrea Di NisioDepartment of Psychology and Health Sciences, Pegaso University, Naples, Italy.
Paola AnseriniSSD Fisiopatologia Della Riproduzione Umana (FRU) IRCCS Ospedale Policlinico San Martino Di Genova, Genoa, Italy.
Carlo ForestaUnit of Andrology and Medicine of Human Reproduction, Department of Medicine - DIMED, University of Padova, Via Giustiniani, 2, Padua, 35128, Italy. carlo.foresta@unipd.it.ORCID http://orcid.org/0000-0002-6576-2183
Group of Special Interest for Environment of the Italian Society of Fertility, Sterility, Reproductive Medicine (SIFES-MR)

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Environmental changes are a growing global concern, and their impact on reproductive health remains incompletely understood. In this narrative review, conducted on behalf of the Italian Society of Fertility and Sterility and Reproductive Medicine (SIFES-MR), we examined the impact of the environment on male fertility, considering endocrine-disrupting chemicals (EDCs), air pollution, and global warming, with the aim of identifying strategies to improve reproductive outcomes. Scientific literature demonstrates that all these aspects may contribute to a decline in reproductive health, impairing sperm count, motility, and morphology as well as reducing testicular hormonal function. Future research should focus on the role of environmental factors in male hypogonadism, impaired spermatogenesis, genital abnormalities, and transgenerational effects.

Indexed as

Endocrine DisruptorsFertilityGlobal WarmingInfertility, MaleHumansItalyMaleReproductive MedicineEndocrine DisruptorsAir pollutionEndocrine disruptors (EDC)Global warmingMale fertilitySperm

Identifiers

PMID41068550
PMCPMC12705501

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.