ArticleJournal of physiology and biochemistry2025
Patterns of circulating cytokines after 2 types of exercise in active type-1 diabetic patients.
Article in Journal of physiology and biochemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Acute Cytokine Responses to High-Intensity Intermittent Exercise in Humans: A Systematic Review.International journal of molecular sciences · 2026Pooled it
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Authors and funding
9 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Aerobic training (beneficial for type 1 diabetes mellitus (T1DM) patients) could result boring, leading to inactivity or suboptimal performance. Therefore, High-Intensity Interval Training (HIIT) could be an appealing alternative. The present study aimed to compare modulation of certain inflammatory cytokines in T1DM participants performing aerobic vs. HIIT routines. We recruited 26 T1DM male subjects: ages 18-40, T1DM ≥ 2 years, glycated hemoglobin < 8.5%, stable insulin regimen for 6 months, minimum 90 min weekly physical activity and completion of International Physical Activity Questionnaire (IPAQ). IPAQ:2 corresponds to moderate activity and IPAQ:3 to intense physical activity. Participants performed a single aerobic or HIIT session separated by at least 72 h. Blood plasma samples were collected 20 min before and after each session. Cytokines were measured using LUMINEX technique. After aerobic exercise, pro-inflammatory cytokines interleukin (IL)-1β, IL-6, IL-7, IL-8, IL-17 A, tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ) showed no significant differences in participants (IPAQ:2 and 3). Only anti-inflammatory cytokine IL-2 increased significantly in IPAQ:3 participants. Compared to pre-exercise, post-exercise HIIT situation presented a similar pattern. The 4 participants (IPAQ:3) that voluntarily followed a 12-week HIIT routine, showed significant increases in IL-7, IL-8, and TNF- α, and the detection of the anti-inflammatory cytokine IL-22. Altogether, these results suggest that HIIT favors the presence of some pro-inflammatory cytokines. The anti-inflammatory action of certain cytokines, such as IL-22, should be considered for a possible compensatory action. Nevertheless, programs of interval exercises at moderate intensity could be at the moment a safe option for T1DM patients.
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