SynthesisHypertension research : official journal of the Japanese Society of Hypertension2025
Effects of renin-angiotensin system inhibitors in cancer patients: a systematic review and meta-analysis of randomized controlled trials.
Synthesis in Hypertension research : official journal of the Japanese Society of Hypertension, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Recent updates and perspectives in "Onco-hypertension".Hypertension research : official journal of the Japanese Society of Hypertension · 2026Review
- Heart failure induced by cancer therapies: focus on targeted agents, mechanisms, risk prediction, and clinical management.Frontiers in pharmacology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cardiotoxicity is a growing concern in cancer patients receiving chemotherapy. Renin-angiotensin system (RAS) inhibitors, including angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARBs), are widely used for cardiovascular protection, but their role in cancer care remains uncertain. We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) to evaluate the effects of RAS inhibitors on cardiotoxicity, dyspnea, and quality of life (QOL) in patients with malignancies. A comprehensive literature search was performed using PubMed, Embase, Web of Science, and the Cochrane Library, from which 15 eligible RCTs were identified. These trials compared RAS inhibitor users and non-users. Group differences were analyzed using mean differences (MDs) or odds ratios (ORs), with heterogeneity assessed by the I² statistic. Pooled results suggested a possible association between RAS inhibitor use and higher left ventricular ejection fraction (LVEF) compared to controls (MD 4.42%, 95% CI -0.02 to 8.85; I² = 96%). Subgroup analysis revealed significant benefit in patients receiving HER2-targeted therapy and those undergoing non-specific chemotherapy, while no advantage was seen in patients treated with anthracyclines and HER2 blockade. RAS inhibitors showed limited benefit in anthracycline regimens. No significant reduction in cardiotoxicity was observed (OR 0.66, 95% CI 0.19-2.30). Additionally, two trials evaluating ACE inhibitors with beta-blockers demonstrated additive effects in preventing LVEF decline in high-risk populations. One trial also reported improved dyspnea with ACE inhibitors in lung cancer. RAS inhibitors may help preserve cardiac function in cancer patients, but current evidence is inconclusive. Confirmation through large-scale RCTs is warranted.
Indexed as
Identifiers
41068418What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.