Evidence map›Paper›PMID 41068365›Full record

ArticleScientific reports2025

The efficacy of selected Ghanaian herbal antimalarials against laboratory strains and clinical isolates of Plasmodium falciparum.

Silas N Yeboah, Mina Ansong, Deborah Clotworthy, Priscilla E Domie, Jersley D Chirawurah, Collins K Awiaga, Charles Mensah, Mona-Liza E Sakyi, Edem Adika, Collins M Morang'a and 3 more

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Public Health Perspectives on IntegratingTropical medicine and infectious disease · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Silas N YeboahWest African Center for Cell Biology of Infectious Pathogens (WACCBIP), College of Basic and Applied Sciences, University of Ghana, Legon, Accra, Ghana.
Mina AnsongWest African Center for Cell Biology of Infectious Pathogens (WACCBIP), College of Basic and Applied Sciences, University of Ghana, Legon, Accra, Ghana.
Deborah ClotworthyWest African Center for Cell Biology of Infectious Pathogens (WACCBIP), College of Basic and Applied Sciences, University of Ghana, Legon, Accra, Ghana.
Priscilla E DomieWest African Center for Cell Biology of Infectious Pathogens (WACCBIP), College of Basic and Applied Sciences, University of Ghana, Legon, Accra, Ghana.
Jersley D ChirawurahWest African Center for Cell Biology of Infectious Pathogens (WACCBIP), College of Basic and Applied Sciences, University of Ghana, Legon, Accra, Ghana.
Collins K AwiagaWest African Center for Cell Biology of Infectious Pathogens (WACCBIP), College of Basic and Applied Sciences, University of Ghana, Legon, Accra, Ghana.
Charles MensahWest African Center for Cell Biology of Infectious Pathogens (WACCBIP), College of Basic and Applied Sciences, University of Ghana, Legon, Accra, Ghana.
Mona-Liza E SakyiWest African Center for Cell Biology of Infectious Pathogens (WACCBIP), College of Basic and Applied Sciences, University of Ghana, Legon, Accra, Ghana.
Edem AdikaWest African Center for Cell Biology of Infectious Pathogens (WACCBIP), College of Basic and Applied Sciences, University of Ghana, Legon, Accra, Ghana.
Collins M Morang'aWest African Center for Cell Biology of Infectious Pathogens (WACCBIP), College of Basic and Applied Sciences, University of Ghana, Legon, Accra, Ghana.
Gordon A AwandareWest African Center for Cell Biology of Infectious Pathogens (WACCBIP), College of Basic and Applied Sciences, University of Ghana, Legon, Accra, Ghana.
Yaw AniwehWest African Center for Cell Biology of Infectious Pathogens (WACCBIP), College of Basic and Applied Sciences, University of Ghana, Legon, Accra, Ghana. yaniweh@ug.edu.gh.
Lucas N Amenga-EtegoWest African Center for Cell Biology of Infectious Pathogens (WACCBIP), College of Basic and Applied Sciences, University of Ghana, Legon, Accra, Ghana. lamengaetego@ug.edu.gh.

Funding

Bill and Melinda Gates Foundation INV-050873National Institute of Health and Care Research NIHR134717
6 · The paper itself

Abstract

The recurrent emergence of drug-resistant Plasmodium parasites threatens malaria control and elimination strategies. In Ghana, there is a growing traditional medicine (TM) sector to support health delivery. In particular, the popularity of these alternative herbal malaria treatments is rapidly growing due to easy access, low cost, and perceived benefits. Some of these herbal malaria medicines are indicated to contain compounds that are in the same chemical classes as standard ACT partner drugs (e.g., quinolines). Thus, this study sought to evaluate the efficacy of selected antimalarial herbal drugs against Plasmodium falciparum parasites. In the study, twenty commercially available liquid formulations of antimalarial herbal medicines were obtained from drug stores and pharmacies within Madina, Accra, Ghana. The formulations were lyophilized and reconstituted into 50 mg/ml stock solutions. Following this, in vitro growth inhibition assays were used to assess the anti-plasmodial activity of these formulations against five laboratory strains and two clinical isolates of P. falciparum. The data from this study shows that of the 20 herbal products tested, 30.0% (n = 6) had potent activity across the six parasite strains screened with half-maximal inhibitory concentration (IC

Indexed as

AntimalarialsMalaria, FalciparumPlant ExtractsPlasmodium falciparumGhanaHumansParasitic Sensitivity TestsAntimalarialsPlant Extracts

Identifiers

PMID41068365
PMCPMC12511297

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.