ArticlePediatric research2026
The neonatal SOFA score in very preterm neonates with early-onset sepsis.
Article in Pediatric research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSepsis is associated with increased neonatal morbidity and mortality. The Neonatal Sequential Organ Failure Assessment (nSOFA) score was developed as a tool to assess neonates with late-onset sepsis (LOS). Absolute values and changes in nSOFA scores are associated with mortality in LOS. Few studies have investigated the nSOFA score in neonatal early-onset sepsis (EOS). This study assesses the relationship of the nSOFA score with morbidity in preterm neonates with EOS.
methodsRetrospective, single-center, cohort study. nSOFA scores were determined for very preterm neonates at seven time points within the first 36 hours of life. Peak and median nSOFA scores were compared between (i) survivors with versus without major morbidity (ii) survivors without major morbidity versus the combined outcome of mortality or major morbidity and (iii) survivors versus non-survivors.
resultsPeak and median nSOFA scores were significantly higher in survivors with versus without major morbidity. That was also true for the combined outcome of mortality or major morbidity. Peak and median nSOFA scores trended higher in non-survivors versus survivors.
conclusionsThe nSOFA score discriminates between very preterm neonates likely (versus unlikely) to develop major morbidity. The nSOFA score may have applicability as an assessment tool in neonatal EOS. IMPACT: The neonatal Sequential Organ Failure Assessment (nSOFA) score provides an operationalized assessment of organ dysfunction in late-onset neonatal sepsis. This study demonstrates the nSOFA score's utility in early-onset sepsis (EOS). This study provides data to support the nSOFA score's utility in discriminating major morbidity and mortality in neonates < 32 weeks gestational age with EOS. A higher nSOFA score was associated with increased morbidity in neonates < 32 weeks gestational age with EOS. A validated nSOFA score for EOS has the potential to improve prognostication and provide a basis for risk-stratifying neonates with EOS.
Indexed as
Identifiers
41068313What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.