ArticleCommunications biology2025
Immediate-early genes Arc and c-Fos show divergent brain-wide expression following contextual fear conditioning.
Article in Communications biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Acquisition-Recruited and MOR-Expressing Striatal dMSNs Differentially Regulate Extinction and Cue-Induced Relapse of Alcohol Seeking.Addiction biology · 2026Article
- Article
- An acute dose of glyphosate alters novel object exploration and hippocampal cFos expression in a sex-dependent manner in wildtype mice.Neuroscience · 2026Article
- Let's talk about sex: Male and female mice show similar fear memory retention despite hippocampal activity differences during encoding and consolidation.bioRxiv : the preprint server for biology · 2026Article
- Time series analysis reveals the effect of shear stress profile on endothelial gene expression.BMC cardiovascular disorders · 2026Article
- Signaling Connectomics: A Brain-wide Framework for Intercellular Communication.Experimental neurobiology · 2026Article
- Simultaneous brain-wide single-cell recording resolves spatiotemporal memory architecture.bioRxiv : the preprint server for biology · 2026Article
- Behavioral and brain-wide neural signatures of sundowning in Alzheimer's disease.Research square · 2026Article
- Emerging roles of circular RNAs and enhancer RNAs: new insights into the development and management of neurodegenerative disorders.Biomarker research · 2026Review
- HIIT-induced lactate/GPR81 signaling with dual branches converging on ERK1/2 contributes to hippocampal synaptic remodeling and memory improvement.Frontiers in cell and developmental biology · 2026Article
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Authors and funding
4 authors.
Funding
Abstract
Encoding or retrieving a fear memory induces activity across the entire brain. Neurons involved in these processes are often identified by the expression of immediate-early genes (IEGs), but the extent to which the patterns of this expression correspond between IEGs has not been well characterized. Here, male mice were administered either context exposure (no shock) or 3-shock contextual fear conditioning and euthanized 1 h after encoding, retrieval 1 day later, or retrieval 5 days later. Brain tissue was immunostained for Arc and c-Fos protein, and expression was quantified across several brain regions. We find that expression of the two IEGs substantially diverges, with fewer than 50% of total labeled cells expressing both markers across memory states. Furthermore, memory state broadly influences Arc
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