Cardiac remodeling pathways do not accelerate disease onset and severity in a mouse model of PLN-R14del cardiomyopathy.

Liu Sun, Elisabeth M Schouten, Karla Arevalo Gomez, Vivian Oliveira Nunes Teixeira, Herman H W Silljé

Abstract read

In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Liu SunDepartment of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

Elisabeth M SchoutenDepartment of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

Karla Arevalo GomezDepartment of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

Vivian Oliveira Nunes TeixeiraDepartment of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

Herman H W SilljéDepartment of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. h.h.w.sillje@umcg.nl.

Funding

CarMa 01-003-2022-0358China Scholarship Council Grant 202008230186 to L.S.Dutch Heart Foundation 2018-30 (CVON-PREDICT2)

6 · The paper itself

Abstract

PLN-R14del is a pathogenic Phospholamban (PLN) gene variant, characterized by ventricular arrhythmias and dilated cardiomyopathy in heterozygous carriers. Disease development is highly heterogeneous, indicating involvement of additional disease triggers, influencing both the onset and severity of the disease. A heterozygous PLN-R14del mouse model (R14

Indexed as

Calcium-Binding ProteinsCardiomyopathiesCardiomyopathy, DilatedVentricular RemodelingAnimalsDisease Models, AnimalMaleMicePhospholambanCalcium-Binding ProteinsPhospholambanCardiac pressure overloadCardiac remodelingCardiomyocytes hypertrophyPhospholamban arginine 14 deletion cardiomyopathy

Identifiers

PMID41068173

DOI10.1038/s41598-025-19321-y

PMCPMC12511440

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.