Articlenpj aging2025
Timing and duration of calorie restriction determine its impact on ovarian aging in female mice.
Article in npj aging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Article
- Nutritional Regulation of Ovarian Bioenergetics: Implications for Reproductive Aging and Female Infertility.Nutrients · 2026Review
- Article
- The role of diet in the pathogenesis and management of premature ovarian insufficiency.Frontiers in nutrition · 2026Review
- Age-related hearing loss persisted in mice that had demonstrated improved healthspan, reduced inflammaging and extended lifespan following expression of the naked mole-rat transgene for hyaluronan synthase 2.Frontiers in aging · 2026Article
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
This study investigated how the timing and duration of 30% caloric restriction (CR) affect ovarian aging in mice. Mice were assigned to one of four groups: ad libitum (AL) control, long-term CR (3-11 months; CR/CR), early short-term CR (3-7 months; CR/AL), and late short-term CR (7-11 months; AL/CR). Long-term CR reduced body mass, improved insulin sensitivity, preserved the ovarian primordial follicle reserve, and attenuated ovarian macrophage infiltration compared to AL-fed mice. Metabolic benefits from CR were quickly reversed upon returning to AL feeding. Short-term CR, whether initiated early or late, did not preserve the ovarian reserve. Some benefits were observed with an early start CR, including reduced ovarian collagen deposition at 7 months and reduced macrophage infiltration at 11 months. Our findings indicate that only long-term CR preserves the ovarian reserve. Short-term CR positive effects on other ovarian aging hallmarks depended on an early age of onset.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.