Evidence map›Paper›PMID 41068089›Full record

ArticleNature communications2025

Size-variable self-feedback nanomotors for glioblastoma therapy via mitochondrial mineralization.

Tiantian Chen, Yu Duan, Yingjie Wang, Tiantian Liang, Shiluan Liu, Xue Xia, Chun Mao, Mimi Wan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Tiantian Chen *State Key Laboratory of Microbial Technology, National and Local Joint Engineering Research Center of Biomedical Functional Materials, School of Chemistry and Materials Science, Nanjing Normal University, Nanjing, P. R. China.
Yu Duan *State Key Laboratory of Microbial Technology, National and Local Joint Engineering Research Center of Biomedical Functional Materials, School of Chemistry and Materials Science, Nanjing Normal University, Nanjing, P. R. China.
Yingjie WangState Key Laboratory of Microbial Technology, National and Local Joint Engineering Research Center of Biomedical Functional Materials, School of Chemistry and Materials Science, Nanjing Normal University, Nanjing, P. R. China.
Tiantian LiangState Key Laboratory of Microbial Technology, National and Local Joint Engineering Research Center of Biomedical Functional Materials, School of Chemistry and Materials Science, Nanjing Normal University, Nanjing, P. R. China.
Shiluan LiuState Key Laboratory of Microbial Technology, National and Local Joint Engineering Research Center of Biomedical Functional Materials, School of Chemistry and Materials Science, Nanjing Normal University, Nanjing, P. R. China.
Xue XiaState Key Laboratory of Microbial Technology, National and Local Joint Engineering Research Center of Biomedical Functional Materials, School of Chemistry and Materials Science, Nanjing Normal University, Nanjing, P. R. China.
Chun MaoState Key Laboratory of Microbial Technology, National and Local Joint Engineering Research Center of Biomedical Functional Materials, School of Chemistry and Materials Science, Nanjing Normal University, Nanjing, P. R. China. maochun@njnu.edu.cn.ORCID http://orcid.org/0000-0003-4085-3414
Mimi WanState Key Laboratory of Microbial Technology, National and Local Joint Engineering Research Center of Biomedical Functional Materials, School of Chemistry and Materials Science, Nanjing Normal University, Nanjing, P. R. China. wanmimi@njnu.edu.

Funding

National Natural Science Foundation of China (National Science Foundation of China) 22175096
6 · The paper itself

Abstract

Developing targeted treatment for glioblastoma is crucial but challenging. Herein, we propose a size-variable self-feedback nanomotor system, utilizing the unique high-calcium microenvironment of glioblastoma to prevent its progression through mitochondrial mineralization. It comprises three components: a self-feedback degradable lipid shell (containing nitric oxide-releasing lipid and nitric oxide-responsive degradable lipid), a motion nanomotor core (containing L-arginine derivatives and carboxyl-rich zwitterionic monomers for Ca

Indexed as

Brain NeoplasmsGlioblastomaMitochondriaNanoparticlesAnimalsBlood-Brain BarrierCalciumCell Line, TumorCurcuminHumansLipidsMiceNitric OxideTumor MicroenvironmentCalciumCurcuminLipidsNitric Oxide

Identifiers

PMID41068089
PMCPMC12511397

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.