ArticleNature communications2025
Amplified copper ion interference and immunomodulation using self-thermophoretic nanomotors to treat refractory implant-associated biofilm infections.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Guanidine-quaternary ammonium polymer-derived carbon dots differentially modulate bacterial respiration and osteoblast mitochondria to resolve infection and foster osteointegration.Bioactive materials · 2027Article
- Bio-adhesive cationic carbon dots enable photodynamic reactive oxygen species generation for cariogenic biofilm suppression.Materials today. Bio · 2026Article
- Deciphering Augmented Dual-ROS-Driven Biofilm Eradication by Facilitating Long-Range Spatial Charge Decoupling in Polymer Carbon Dots.Angewandte Chemie (International ed. in English) · 2026Article
- Biomaterial-Driven Modulation of Macrophage Polarization in an Experimental Environment of Implant-Associated Infection Mediated byJournal of functional biomaterials · 2026Review
- Iron-Hijacking Trojan Horse Nanoplatform Combats Implant-Associated Biofilm Infections Through Immuno-Fibrotic Remodeling.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Ultrasound-activated piezoelectric Bi@Bi-MOF enables STING-mediated immunotherapy for implant-associated infections.Journal of nanobiotechnology · 2026Article
- Interfacial Chemistry-Tailored Silica&Metal-Based Heterostructures: from Rational Design to Antibacterial Applications.Small (Weinheim an der Bergstrasse, Germany) · 2026Review
- Synergistic bactericidal activity of a ginsenoside-copper nano-agent against gram-positive and gram-negative biofilm bacteria.Frontiers in microbiology · 2026Article
- Recent Advances in Functionalized Gold Nanoprobes for Photoacoustic Imaging Analysis of Diseases.Sensors (Basel, Switzerland) · 2025Review
- HJournal of nanobiotechnology · 2025Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Orthopedic implant-associated biofilm infections (IABIs) are refractory to elimination because of the dense biofilm formation and local immunosuppressive microenvironment. Herein, we propose a copper-based therapeutic strategy to treat IABIs. Initially, the Janus bisphere nanostructure is fabricated using mesoporous silicon nanoparticle (MSN) with gold nanoparticle. Subsequently, copper peroxide (CP) nanodots are encapsulated within the MSN to form the final nanomotor Motor@CP. Our Motor@CP exhibits remarkable autonomous movement through near-infrared (NIR)-propelled self-thermophoretic propulsion, effectively penetrating dense biofilms and delivering CP. Notably, the acidic microenvironment facilitates CP decomposition into copper(II) and hydrogen peroxide. This process further generates hydroxyl radicals (•OH), extensively destroying biofilm integrity and enhancing intracellular uptake of copper ions that trigger bacterial cuproptosis-like death. Furthermore, Motor@CP markedly reprograms infiltrating macrophages toward pro-inflammatory phenotypes, thereby promoting an antimicrobial immune response. Overall, this presents a promising approach that leverages amplified copper ion interference and macrophage reprogramming to combat refractory orthopedic IABIs.
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Registered trials
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