Evidence map›Paper›PMID 41068080›Full record

ArticleSignal transduction and targeted therapy2025

Single-cell RNA-seq reveals cell type-specific molecular and genetic associations with primary open-angle glaucoma.

Huaping Tian, Yuhong Chen, Tujing Zhao, Lin Ye, Hongjing Li, Zheng Li, Wenqiao Qiu, Wentao Wang, Runze Li, Fulin Liu and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Signal transduction and targeted therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
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  7. Observational
  8. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Huaping Tian *Genetic Diseases Key Laboratory of Sichuan Province, Center for Medical Genetics, Department of Laboratory Medicine, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Yuhong Chen *Department of Ophthalmology and Visual Science, Eye and Ear Nose Throat Hospital, Shanghai Medical School, Fudan University, Shanghai, China.
Tujing Zhao *Genetic Diseases Key Laboratory of Sichuan Province, Center for Medical Genetics, Department of Laboratory Medicine, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Lin Ye *Genetic Diseases Key Laboratory of Sichuan Province, Center for Medical Genetics, Department of Laboratory Medicine, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Hongjing LiGenetic Diseases Key Laboratory of Sichuan Province, Center for Medical Genetics, Department of Laboratory Medicine, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Zheng LiGenetic Diseases Key Laboratory of Sichuan Province, Center for Medical Genetics, Department of Laboratory Medicine, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Wenqiao QiuGenetic Diseases Key Laboratory of Sichuan Province, Center for Medical Genetics, Department of Laboratory Medicine, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Wentao WangDepartment of Ophthalmology and Visual Science, Eye and Ear Nose Throat Hospital, Shanghai Medical School, Fudan University, Shanghai, China.
Runze LiGenetic Diseases Key Laboratory of Sichuan Province, Center for Medical Genetics, Department of Laboratory Medicine, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Fulin LiuGenetic Diseases Key Laboratory of Sichuan Province, Center for Medical Genetics, Department of Laboratory Medicine, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Haojue XueDepartment of Ophthalmology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
Ruilin LiaoGenetic Diseases Key Laboratory of Sichuan Province, Center for Medical Genetics, Department of Laboratory Medicine, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Chao QuDepartment of Ophthalmology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
Jie LiDepartment of Ophthalmology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
Liang ZouSchool of Food and Biological Engineering, Chengdu University, Chengdu, Sichuan, China.
Yi ShiGenetic Diseases Key Laboratory of Sichuan Province, Center for Medical Genetics, Department of Laboratory Medicine, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Zhenglin YangGenetic Diseases Key Laboratory of Sichuan Province, Center for Medical Genetics, Department of Laboratory Medicine, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China. yangzhenglin@cashq.ac.cn.
Lulin HuangGenetic Diseases Key Laboratory of Sichuan Province, Center for Medical Genetics, Department of Laboratory Medicine, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China. huangluling@yeah.net.

Funding

National Natural Science Foundation of China (National Science Foundation of China) 81970839，82271105
6 · The paper itself

Abstract

Primary open-angle glaucoma (POAG), a leading cause of irreversible blindness, involves complex neurodegeneration in which the contribution of systemic immunity remains enigmatic. Here, we dissect the circulating immune landscape in POAG patients via high-resolution single-cell RNA sequencing of ~1.4 million peripheral blood mononuclear cells (PBMCs) from 110 patients and 110 controls of Chinese ancestry. We revealed significant immune remodeling in POAG, characterized by increased CD4

Indexed as

Glaucoma, Open-AngleSingle-Cell AnalysisAgedAnimalsFemaleHumansInterferon-gammaLeukocytes, MononuclearMaleMiceMiddle AgedQuantitative Trait LociRNA-SeqSingle-Cell Gene Expression AnalysisTumor Necrosis Factor-alphaIFNG protein, humanInterferon-gammaTumor Necrosis Factor-alpha

Identifiers

PMID41068080
PMCPMC12511369

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.