ArticleBritish journal of anaesthesia2026
Risk factors, outcomes, and early prediction of cardiac surgery-associated acute kidney injury: a post hoc subgroup analysis of the Epidemiology of Surgery Associated Acute Kidney Injury study.
Article in British journal of anaesthesia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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5 citing papers in PubMed.
- Development of a multivariable clinical prediction model for acute kidney injury after valve replacement surgery: incremental value of the triglyceride-glucose body mass index.Journal of thoracic disease · 2026Article
- Immediate postoperative urine dipstick occult blood positivity: a simple and early indicator of high-risk acute kidney injury after on-pump cardiac surgery.BMC nephrology · 2026Article
- Mitochondrial calcium uniporter-mediated mitochondrial dynamics imbalance contributes to contrast medium-induced renal tubular cell injury.Frontiers in molecular biosciences · 2026Article
- Severity matters: reframing cardiac surgery-associated acute kidney injury.Critical care science · 2026Article
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7 authors.
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Abstract
backgroundCardiac surgery-associated acute kidney injury (CSA-AKI) is a common and important complication. The risk factors for CSA-AKI remain poorly described. We aimed to identify risk factors for CSA-AKI and develop a risk score for persistent CSA-AKI.
methodsWe performed a post hoc subgroup analysis restricted to patients who underwent cardiac surgery within the Epidemiology of Surgery Associated Acute Kidney Injury (EPIS-AKI) study. CSA-AKI was defined as AKI (according to the Kidney Disease: Improving Global Outcomes criteria) within 72 h after surgery. Persistent CSA-AKI was defined as CSA-AKI lasting >48 h. We performed multivariable logistic regression analyses to identify risk factors for CSA-AKI and related outcomes.
resultsThe original EPIS-AKI study included 3101 cardiac surgery patients. Of these, 802 (25.9%) developed CSA-AKI. On follow-up, 279 of the 802 patients (34.8%) developed persistent CSA-AKI. We identified independent risk factors for CSA-AKI, moderate/severe CSA-AKI, and persistent CSA-AKI. Patients with persistent CSA-AKI had a higher ICU and hospital mortality compared with patients with transient CSA-AKI. We developed a risk score for predicting persistent CSA-AKI with an area under the receiver operating characteristic curve of 0.79 (95% confidence interval, 0.7355-0.8457).
conclusionsOverall, 25% of cardiac surgery patients developed cardiac surgery-associated acute kidney injury, and 33% of these patients experienced persistent cardiac surgery-associated acute kidney injury, which was associated with poor outcomes. We developed a risk score for predicting persistent cardiac surgery-associated acute kidney injury, the 'EPIS CSA-AKI risk score'. Pending further external validation, the score might be used to identify patients who have a high risk for developing persistent cardiac surgery-associated acute kidney injury.
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