Evidence map›Paper›PMID 41067882›Full record

ArticleJournal for immunotherapy of cancer2025

Exceptional tumor-free survival of a patient with metastatic intrahepatic cholangiocarcinoma after surgery and personalized peptide vaccination: revisiting a striking case.

Ana Maia, Juliane Schuhmacher, Silvio Nadalin, Alfred Königsrainer, Karolin Thiel, Annika Nelde, Raphael S Zinser, Christopher Schroeder, Sven Mattern, Stephan Singer and 4 more

Abstract readCase Reports
In one paragraph

Article in Journal for immunotherapy of cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Advances in Immunotherapy for Intrahepatic Cholangiocarcinoma.International journal of molecular sciences · 2026
    Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Ana MaiaInstitute of Immunology, University and University Hospital Tübingen, Tübingen, Germany.ORCID http://orcid.org/0000-0003-1261-7211
Juliane SchuhmacherInstitute of Immunology, University and University Hospital Tübingen, Tübingen, Germany.
Silvio NadalinDepartment of General, Visceral and Transplant Surgery, University Hospital Tübingen, Tübingen, Germany.
Alfred KönigsrainerDepartment of General, Visceral and Transplant Surgery, University Hospital Tübingen, Tübingen, Germany.
Karolin ThielDepartment of General, Visceral and Transplant Surgery, University Hospital Tübingen, Tübingen, Germany.ORCID http://orcid.org/0000-0002-7328-7589
Annika NeldeCluster of Excellence iFIT (EXC2180) 'Image-Guided and Functionally Instructed Tumor Therapies', University of Tübingen, Tübingen, Germany.ORCID http://orcid.org/0000-0001-8504-8481
Raphael S ZinserInstitute of Immunology, University and University Hospital Tübingen, Tübingen, Germany.
Christopher SchroederInstitute of Medical Genetics and Applied Genomics, University Hospital Tübingen, Tübingen, Germany.ORCID http://orcid.org/0000-0002-9283-3012
Sven MatternInstitute of Pathology and Neuropathology, University Hospital Tübingen, Tübingen, Germany.ORCID http://orcid.org/0000-0001-7362-0209
Stephan SingerInstitute of Pathology and Neuropathology, University Hospital Tübingen, Tübingen, Germany.
Hans BösmüllerInstitute of Pathology and Neuropathology, University Hospital Tübingen, Tübingen, Germany.ORCID http://orcid.org/0000-0002-7515-435X
Hans-Georg RammenseeInstitute of Immunology, University and University Hospital Tübingen, Tübingen, Germany.ORCID http://orcid.org/0000-0003-1614-2647
Markus W Löffler *Institute of Immunology, University and University Hospital Tübingen, Tübingen, Germany Markus.Loeffler@uni-tuebingen.de cecile.gouttefangeas@uni-tuebingen.de.ORCID http://orcid.org/0000-0003-2513-1317
Cécile Gouttefangeas *Institute of Immunology, University and University Hospital Tübingen, Tübingen, Germany Markus.Loeffler@uni-tuebingen.de cecile.gouttefangeas@uni-tuebingen.de.ORCID http://orcid.org/0000-0002-6410-2378

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cholangiocarcinomas are rare but aggressive liver tumors of high lethality with scarce treatment options. Here we report on the follow-up of a patient diagnosed with an intrahepatic cholangiocarcinoma who experienced repeated tumor recurrences including distant metastasis, therefore facing a dismal prognosis. At present, this patient is tumor-free for more than 8 years following repeated surgery and application of two successive personalized vaccines. In-depth functional immune cell analyses revealed a dominant CD4

Indexed as

Bile Duct NeoplasmsCancer VaccinesCholangiocarcinomaVaccines, SubunitDisease-Free SurvivalFemaleHumansMiddle AgedPrecision MedicineCancer VaccinesVaccines, Subunitcancer vaccinecase reportCD4+T cellsmetastatic cholangiocarcinoma

Identifiers

PMID41067882
PMCPMC13059883

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.