ArticleClinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association2026
From Pixels to Peristalsis: Comparing Achalasia Diagnosis With Artificial Intelligence With Expert Endoscopists.
Article in Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
BACKGROUND &
aimsEsophageal motility disorders, such as achalasia, require the use of multiple tests to establish a diagnosis. Patients are first assessed with upper endoscopy, but subtle disease indicators are often overlooked during the procedure leading to delayed diagnosis. Artificial intelligence has the potential to prevent these misdiagnoses and serve as an early screening tool to enhance the physician's decision-making.
methodsWe developed a video-based transformer model capable of detecting achalasia from upper endoscopy videos. Videos were collected from 1203 patients who presented with dysphagia between August 2018 and January 2024. The model performance was compared with a baseline of 2 expert physicians independently reviewing each video and consulting one another for a final consensus decision. A test set of 95 patients was used to evaluate the physician consensus and model performance based on ground truth labels obtained via high-resolution manometry the Chicago Classification v4.0 scheme.
resultsThe model attained similar performance to the physician consensus on the test set, achieving an accuracy and F1 of 0.926 and 0.821, respectively, compared with the physicians (0.905 and 0.710, respectively). The model also obtained fewer false negatives, achieving a sensitivity and negative predictive value of 0.800 and 0.947, respectively, compared with the physicians (0.550 and 0.893, respectively). Furthermore, the model's attention mechanism emphasized clinically relevant features such as presence of fluid or food in the esophagus, and a tight lower esophageal sphincter.
conclusionsThese results indicate that artificial intelligence can leverage upper endoscopy videos to detect achalasia with an accuracy comparable to that of expert endoscopists.
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