Observational studyJournal of the National Comprehensive Cancer Network : JNCCN2025
Smoking Cessation and Mortality Risk in Cancer Survivorship: Real-World Data From a National Cancer Institute-Designated Cancer Center.
Observational study in Journal of the National Comprehensive Cancer Network : JNCCN, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Article
- Reach, Acceptability, and Effectiveness of Proactive Outreach and Varenicline with Cancer-Focused Counseling for Patients with Cancer: A Pilot Randomized Comparative Effectiveness Trial.JCO oncology advances · 2026Article
- 2D nanomaterial-triggered ferroptosis in cancer therapy.Journal of nanobiotechnology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
Abstract
backgroundAlthough evidence-based tobacco cessation treatments are recommended for all patients with cancer who smoke, they are often underutilized in routine oncology care due to time and resource constraints and limited understanding of the impact of smoking cessation on long-term outcomes in patients with advanced-stage cancer. This study aimed to evaluate the association between smoking cessation and overall survival (OS) in cancer survivors who smoke, across all disease stages.
methodsWe conducted an observational cohort study of 13,282 patients diagnosed with cancer who were evaluated in our outpatient oncology clinics between June and December 2018. Patients who smoked were prospectively followed to evaluate smoking cessation rates over the following 6 months. We assessed the impact of index-visit smoking status and smoking cessation within 6 months on 2-year OS using multivariable Cox proportional hazards models and the Kaplan-Meier method.
resultsCompared with patients who never smoked (n=6,568; 49.5%), those who reported currently smoking (n=1,725; 13.0%) (adjusted hazard ratio for death [aHR], 1.35; CI, 1.20-1.53) or having previously smoked (n=4,989; 37.6%) (aHR, 1.13; CI, 1.03-1.25) at their index visit had increased risk of all-cause mortality. Only 22.1% (n=381) of patients who reported currently smoking at their index visit quit smoking within 6 months. In multivariable analyses, patients who continued to smoke had a higher risk of all-cause mortality (aHR, 1.97; CI, 1.53-2.55) compared with those who had quit smoking. Subgroup analyses by cancer stage revealed an association between continued smoking and all-cause mortality in patients with advanced-stage (III or IV) cancer (aHR, 2.11; 95% CI, 1.60-2.79).
conclusionsPostdiagnosis smoking cessation is associated with improved OS in cancer survivors, including those with advanced-stage cancer. Smoking cessation support should be provided to all cancer survivors who smoke, irrespective of cancer type or stage. Promoting smoking cessation in oncology care settings via systematic implementation efforts may aid in reducing smoking and mortality rates.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.