Evidence map›Paper›PMID 41067246›Full record

ArticlePhysics in medicine and biology2025

Extending the microdosimetry gamma model (MGM) to estimate induced DNA damage and its complexity at macroscopic scale by protons and helium ions.

Victor V Onecha, Jan Schuemann, Harald Paganetti, Alejandro Bertolet

Abstract read
In one paragraph

Article in Physics in medicine and biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Victor V OnechaDepartment of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States of America.ORCID 0000-0002-3531-2851
Jan SchuemannDepartment of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States of America.ORCID 0000-0002-7554-8818
Harald PaganettiDepartment of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States of America.ORCID 0000-0002-6257-2413
Alejandro BertoletDepartment of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States of America.ORCID 0000-0002-9890-693X

Funding

Project 3: Enhanced Sensitivity of Tumors to Proton Beam Therapy: Mechanisms and Biomarkers.P01CA261669 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI HONG, THEODORE S · 2021 to 2025
$14.0M
TOPAS - nBio, a Monte Carlo tool for radiation biology researchR01CA187003 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI SCHUEMANN, JAN PATRICK OSCAR · 2015 to 2024
$4.8M
Radiation dosimetry for alpha-particle radiopharmaceutical therapy and application to pediatric neuroblastomaR00CA267560 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI BERTOLET REINA, ALEJANDRO · 2023 to 2025
$721k
NCI NIH HHS P01 CA261669NCI NIH HHS R00 CA267560NCI NIH HHS R01 CA187003
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

DNA DamageGamma RaysHeliumProtonsRadiometryDNA Breaks, Double-StrandedHumansMonte Carlo MethodPhantoms, ImagingHeliumProtonsDNA damageMGMmicrodosimetryparticle therapyRPTTOPAS-nBio

Identifiers

PMID41067246
PMCPMC12905799

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.