ArticleNeuron2025
Restoration of temporal separability between beta and movement ensemble co-firing with motor recovery.
Article in Neuron, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Amplitude-modulated kilohertz stimulation targeting beta-band activity disrupts motor learning.bioRxiv : the preprint server for biology · 2026Article
- Conserved role of primary motor cortex in the control of prehension in mice and macaques.Cell reports · 2026Article
- Parkinsonism disrupts the population-level organization of cortical dynamics.bioRxiv : the preprint server for biology · 2026Article
- Reopening Motor Learning Windows: Targeted Re-Engagement of Latent Pathways via Non-Invasive Neuromodulation.Life (Basel, Switzerland) · 2026Review
- Shared somatosensory-motor neural population dynamics track motor recovery after stroke.bioRxiv : the preprint server for biology · 2026Article
- Article
- Effects of low-frequency burst stimulation of the motor thalamus on cortical neural co-firing.Brain stimulationArticle
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Authors and funding
8 authors.
Funding
Abstract
Stroke disrupts movement control by damaging descending motor pathways, yet the cortical dynamics underlying recovery remain poorly defined. Using a non-human primate model of primary motor cortex injury with impaired reach-to-grasp control, we examined how dorsal premotor cortex (PMd) activity supports recovery. Specifically, we studied the interaction between beta activity (12-30 Hz), often linked to "idle" states, and execution-related ensemble co-firing quantified with dimensionality reduction. Stroke impaired the temporal separability between beta bursts and movement-related co-firing, leading to slower reaction times and reduced performance. Recovery was associated with increased separability, and during grasping, beta activity progressively declined with recovery. These results indicate that reliable transitions between high-beta idle and high co-firing execution states are important for movement control, whereas pathological beta intrusions during execution degrade performance. Importantly, low-frequency alternating current stimulation (ACS) via a ringtrode interface enhanced temporal separability and improved reach-to-grasp performance, highlighting a potential therapeutic strategy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.