Observational studyPregnancy hypertension2025
Identifying cardiovascular health profiles in early pregnancy: A "Life's Essential 8"-based approach to assessing risk of hypertensive disorders of pregnancy.
Observational study in Pregnancy hypertension, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- The implications of maternal sleep disruption on cardiovascular adaptations and cardiometabolic outcomes.The Lancet. Obstetrics, gynaecology, & women's health · 2026Article
- Association of body mass index with adverse pregnancy outcomes when stratified by cardiovascular health.Pregnancy (Hoboken, N.J.) · 2026Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
objectivesThis study aimed to characterize cardiovascular risk profiles in an obstetric population using American Heart Association's Life's Essential 8 components and investigate which combinations are associated with hypertensive disorders of pregnancy (HDP). STUDY
designSecondary analysis of a prospective observational cohort, Nulliparous Pregnancy Outcomes Study: Monitoring Mothers-to-be (nuMoM2b).
main outcome measuresWe used latent class analysis to identify cardiovascular risk classes using Life's Essential 8 indicators at 6-14 weeks' gestation: blood pressure (BP), body mass index (BMI), and self-reported diet, sleep, smoke exposure, and physical activity. We assessed predictors of class membership and odds of HDP with logistic regression.
resultsWe identified a four-class solution with the following interpretative labels: (1) Healthy Behaviors/Normal BMI & BP (42%), (2) No Physical Activity/Normal BMI & BP (31%), (3) High Snoring/Elevated BMI (18%), and (4) Poor Behaviors/Normal BMI & BP (8%). Compared with the Healthy Behaviors/Normal BMI & BP class, individuals in the other risk profiles were more likely to be unmarried vs. married, Non-Hispanic Black vs. Non-Hispanic White, have government vs. commercial insurance, and report high vs. low periconceptual stress. Two risk profiles were associated with HDP: High Snoring/Elevated BMI had 2.4 times (95% CI 2.1-2.8) the odds and Poor Behaviors/Normal BMI & BP had 1.5 times (95% CI 1.2-1.8) the odds of HDP compared with Healthy Behaviors/Normal BMI & BP.
conclusionsTwo cardiovascular risk profiles-High Snoring/Elevated BMI and Poor Behaviors/Normal BMI & BP-were linked to HDP, emphasizing the potential for personalized, multifactorial interventions targeting modifiable behaviors to reduce risk.
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Registered trials
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