Evidence map›Paper›PMID 41066767›Full record

ArticleJournal of the American Chemical Society2025

Aminoacyl-tRNA Specificity of a Ligase Catalyzing Non-ribosomal Peptide Extension.

Dinh T Nguyen, Josseline S Ramos-Figueroa, Alexander A Vinogradov, Yuki Goto, Mayuresh G Gadgil, Rebecca A Splain, Hiroaki Suga, Wilfred A van der Donk, Douglas A Mitchell

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Chemical Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Dinh T NguyenCarl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, 1206 West Gregory Drive, Urbana, Illinois 61801, United States.ORCID 0000-0002-2101-6808
Josseline S Ramos-FigueroaDepartment of Chemistry and Howard Hughes Medical Institute, University of Illinois at Urbana-Champaign, 600 South Mathews Avenue, Urbana, Illinois 61801, United States.ORCID 0000-0002-7377-8484
Alexander A VinogradovDepartment of Chemistry, Graduate School of Science, The University of Tokyo, 7-3-1, Hongo, Bunkyo, Tokyo 113-0033, Japan.ORCID 0000-0002-8899-0533
Yuki GotoDepartment of Chemistry, Graduate School of Science, The University of Tokyo, 7-3-1, Hongo, Bunkyo, Tokyo 113-0033, Japan.ORCID 0000-0003-4317-0790
Mayuresh G GadgilDepartment of Biochemistry, Vanderbilt University School of Medicine - Basic Sciences, Nashville, Tennessee 37232, United States.ORCID 0000-0003-2749-1682
Rebecca A SplainDepartment of Chemistry and Howard Hughes Medical Institute, University of Illinois at Urbana-Champaign, 600 South Mathews Avenue, Urbana, Illinois 61801, United States.
Hiroaki SugaDepartment of Chemistry, Graduate School of Science, The University of Tokyo, 7-3-1, Hongo, Bunkyo, Tokyo 113-0033, Japan.ORCID 0000-0002-5298-9186
Wilfred A van der DonkCarl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, 1206 West Gregory Drive, Urbana, Illinois 61801, United States.ORCID 0000-0002-5467-7071
Douglas A MitchellDepartment of Biochemistry, Vanderbilt University School of Medicine - Basic Sciences, Nashville, Tennessee 37232, United States.ORCID 0000-0002-9564-0953

Funding

Posttranslational Modifications during Natural Product BiosynthesisR37GM058822 · NIGMS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI VAN DER DONK, WILFRED A. · 2016 to 2025
$2.9M
Genomics-Accelerated Natural Product DiscoveryR01GM123998 · NIGMS · VANDERBILT UNIVERSITY · PI MITCHELL, DOUGLAS ALAN · 2017 to 2024
$2.6M
Discovery and Engineering of RiPP Natural ProductsR35GM158411 · NIGMS · VANDERBILT UNIVERSITY · PI Douglas Alan Mitchell · 2025 to 2026
$1.2M
NIGMS NIH HHS R01 GM123998NIGMS NIH HHS R35 GM158411NIGMS NIH HHS R37 GM058822
6 · The paper itself

Abstract

Peptide aminoacyl-transfer ribonucleic acid ligases (PEARLs) are amide-bond-forming enzymes that extend the main chain of peptides by using aminoacyl-tRNA (aa-tRNA) as a substrate. In this study, we investigated the substrate specificity of the PEARL BhaB

Indexed as

RNA, Transfer, Amino AcylAmino Acyl-tRNA SynthetasesBacillusBiocatalysisPeptidesAmino Acyl-tRNA SynthetasesPeptidesRNA, Transfer, Amino Acyl

Identifiers

PMID41066767
PMCPMC12550832

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.