ArticleJCO precision oncology2025
Role of Circulating Tumor DNA Tumor Fraction in Advanced Non-Small Cell Lung Cancer and Its Impact on Patient Treatment Outcomes: A Prospective Real-World Study.
Article in JCO precision oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Circulating tumor DNA tumor fraction as a biomarker in refractory metastatic colorectal cancer: findings from the CAVE-2 GOIM trial.The journal of liquid biopsy · 2026Article
- Artificial intelligence-powered liquid biopsy in cancer: a paradigm shift in cancer detection and personalized care.Cancer cell international · 2026Review
- Circulating tumor DNA in neoadjuvant therapy for solid tumors.Frontiers in oncology · 2026Review
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeComprehensive genomic profiling (CGP) using targeted panel next-generation sequencing (TP-NGS) is pivotal in the clinical management of advanced non-small cell lung cancer (aNSCLC). Despite the limitations associated with tumor tissue sampling, circulating tumor DNA (ctDNA) presents a promising alternative. This study aims to assess the prognostic value of ctDNA tumor fraction (TF) in aNSCLC. MATERIALS AND
methodsWe conducted a multicenter prospective study in Hong Kong. Patients with aNSCLC provided blood samples within 31 days before treatment initiation, followed by CGP using a validated ctDNA assay.
resultsAmong 878 patients, those with ctDNA TF ≥1% had significantly worse outcomes, with median progression-free survival (PFS) of 13.2 months and overall survival (OS) of 17.6 months compared with the ctDNA TF <1% group (
conclusionOur findings establish ctDNA TF as a clinically relevant biomarker in aNSCLC, providing robust prognostic and predictive information. The findings support the integration of ctDNA TF quantification into routine clinical workflows, reinforcing its role in advancing precision oncology and improving risk stratification and outcomes for patients with aNSCLC.
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