Evidence map›Paper›PMID 41066726›Full record

ArticleJCO precision oncology2025

Sustained Response to Pan-BRAF Inhibitor Plixorafenib (FORE8394, PLX8394) in a Young Adult With Neurodegenerative Langerhans Cell Histiocytosis.

Joanna S Yi, Kathleen S McCarthy, Kate Mazur, Rebecca Kudlaty, Terry Armstrong, Nilesh Desai, Stacie Peacock Shepherd, Daniel Zinn, Jessica Velazquez, Brooks Scull and 2 more

Abstract read
In one paragraph

Article in JCO precision oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Joanna S YiTexas Children's Hospital, Pediatric Hematology/Oncology, Baylor College of Medicine, Houston, TX.ORCID 0000-0002-0914-8728
Kathleen S McCarthyTexas Children's Hospital, Pediatric Hematology/Oncology, Baylor College of Medicine, Houston, TX.
Kate MazurTexas Children's Hospital, Pediatric Hematology/Oncology, Baylor College of Medicine, Houston, TX.
Rebecca KudlatyTexas Children's Hospital, Pediatric Hematology/Oncology, Baylor College of Medicine, Houston, TX.
Terry ArmstrongTexas Children's Hospital, Pediatric Hematology/Oncology, Baylor College of Medicine, Houston, TX.
Nilesh DesaiTexas Children's Hospital, Radiology, Baylor College of Medicine, Houston, TX.
Stacie Peacock ShepherdFORE Biotherapeutics, Philadelphia, PA.
Daniel ZinnTexas Children's Hospital, Pediatric Hematology/Oncology, Baylor College of Medicine, Houston, TX.
Jessica VelazquezTexas Children's Hospital, Pediatric Hematology/Oncology, Baylor College of Medicine, Houston, TX.ORCID 0000-0002-4384-8744
Brooks ScullTexas Children's Hospital, Pediatric Hematology/Oncology, Baylor College of Medicine, Houston, TX.
Carl AllenTexas Children's Hospital, Pediatric Hematology/Oncology, Baylor College of Medicine, Houston, TX.ORCID 0000-0002-6625-739X
Kenneth McClainTexas Children's Hospital, Pediatric Hematology/Oncology, Baylor College of Medicine, Houston, TX.

Funding

PEDIATRIC ONCOLOGY CLINICAL RESEARCH TRAINING PROGRAMK12CA090433 · NCI · BAYLOR COLLEGE OF MEDICINE · PI CARL E ALLEN, Donald W. Parsons · 2002 to 2026
$18.5M
ERK control of Dendritic Cell Differentiation, Homeostasis and DiseaseR01CA154947 · NCI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI CARL E ALLEN, MIRIAM MERAD · 2011 to 2026
$7.0M
The PreVAIL-kIds Common ProtocolR33HD105593 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI ALLEN, CARL E, ANNAPRAGADA, ANANTH V · 2023 to 2023
$6.3M
NCI NIH HHS K12 CA090433NCI NIH HHS R01 CA154947NICHD NIH HHS R33 HD105593
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Identifiers

PMID41066726
PMCPMC12694702

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.