Article in Science (New York, N.Y.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Yajing Gao *Department of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA, USA.ORCID 0000-0002-8836-4452
John P Kennelly *Department of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA, USA.ORCID 0000-0002-4399-3976
Xu XiaoDepartment of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA, USA.ORCID 0000-0002-5033-7627
Emily WhangDepartment of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA, USA.ORCID 0000-0003-0704-6178
Alessandra FerrariDepartment of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA, USA.ORCID 0000-0001-7354-9895
Alexander H BedardDepartment of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA, USA.ORCID 0000-0001-9208-398X
Julia J MackDepartment of Medicine, Division of Cardiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.ORCID 0000-0002-9239-8436
Alexander NguyenDepartment of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA, USA.ORCID 0000-0001-6578-3454
Sonal SrikanthDepartment of Physiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.ORCID 0000-0002-3034-095X
Thomas WestonDepartment of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.ORCID 0000-0003-3720-8633
Lauren F UchiyamaDepartment of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA, USA.ORCID 0000-0002-6574-0064
Whitaker CohnThe Pasarow Mass Spectrometry Laboratory, University of California, Los Angeles, Los Angeles, CA, USA.ORCID 0000-0001-9198-8904
Danielle H ChoDepartment of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA, USA.ORCID 0009-0004-2829-495X
Min Sub LeeDepartment of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA, USA.ORCID 0000-0002-8729-8182
Julian WhiteleggeThe Pasarow Mass Spectrometry Laboratory, University of California, Los Angeles, Los Angeles, CA, USA.
Yousang GwackVatche and Tamar Manoukian Division of Digestive Diseases, Department of Medicine David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.ORCID 0000-0002-2821-9245
Stephen G YoungDepartment of Medicine, Division of Cardiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.ORCID 0000-0001-7270-3176
Steven J BensingerDepartment of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA, USA.ORCID 0000-0002-9657-4206
Peter TontonozDepartment of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA, USA.ORCID 0000-0003-1259-0477
Funding
Mechanisms of nonvesicular cholesterol transportR01HL175773 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI PETER J TONTONOZ · 2024 to 2026
$2.2M
Regulation of the STING pathway under sterile conditionsR01AI146352 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SRIKANTH, SONAL · 2020 to 2023
$1.6M
Membrane cholesterol and vascular inflammationR01HL175240 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI PETER J TONTONOZ · 2025 to 2026
$1.5M
Mechanisms of Dietary Nutrient AbsorptionR01DK142199 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI PETER J TONTONOZ · 2025 to 2026
$1.5M
Mechanistic link between mitochondrial cristae integrity and Th1 responsesR01AI181072 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Yousang Gwack · 2025 to 2026
$1.0M
Distinct functions of Orai1 and Orai2 in naive and effector helper T cellsR21AI130653 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SRIKANTH, SONAL · 2017 to 2018
$424k
Regulation of intestinal lipid metabolism by type-3 immune cytokineK99DK138289 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Yajing Gao · 2025 to 2026
The intrinsic pathways that control membrane organization in immune cells and their impact on cellular functions are poorly defined. We found that the nonvesicular cholesterol transporter Aster-A linked plasma membrane (PM) cholesterol availability in CD4 T cells to systemic metabolism. Aster-A was recruited to the PM during T cell receptor (TCR) activation, where it facilitated the removal of accessible cholesterol. Loss of Aster-A increased cholesterol accumulation in the PM, which enhanced TCR nanoclustering and signaling. Aster-A associated with stromal interaction molecule 1 (STIM1) and negatively regulated calcium (Ca
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
T cell cholesterol transport links intestinal immune responses to dietary lipid absorption. · full record | OpenQuestion