ArticlePloS one2025
The relationship between anemia and sleep disturbances among older Chinese adults: The mediating role of handgrip strength.
Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSleep plays an important role in human health, and anemia can lead to a continuous deterioration of sleep. However, the association and mechanism between anemia and sleep disturbances remain unclear. This study aimed to examine the relationship between anemia and sleep disturbances among older Chinese adults, in addition to examining the mediating role of handgrip strength in this relationship.
methodsThis research utilized data from the 2015 China Health and Retirement Longitudinal Study (CHARLS). Following the application of specific inclusion and exclusion criteria, a total of 6,057 Chinese adults aged 60 and above were finally selected as the analysis samples. The dependent variable was sleep disturbances (yes/no), with anemia (present/absent) serving as the main independent variables. Handgrip strength was employed as the mediating factor. Multivariable-adjusted logistic regression analyses were conducted to investigate the relationships among anemia, handgrip strength, and sleep disturbances. Additionally, bootstrap tests were performed to assess the mediating role of handgrip strength in the association between anemia and sleep disturbances.
resultsIn the unadjusted model, a positive association was observed between anemia and sleep disturbances (OR: 1.22, 95% CI: 1.08-1.38), whereas handgrip strength exhibited a negative association with sleep disturbances (OR: 0.95, 95% CI: 0.93-0.97). These associations persisted even after adjusting for covariates in Models 1, 2, and 3. Furthermore, handgrip strength was found to significantly mediate the link between anemia and sleep disturbances(mediating effect = 5.75x10 -3), with the mediating effect accounting for 15.67% of the association.
conclusionsThe study indicate that anemia is positively associated with an increased risk of sleep disturbances among older Chinese individuals, with handgrip strength acting as a significant mediator in this relationship. This study provides valuable references for improving the sleep quality of older adults.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.