ArticlePloS one2025
High-density perimetry in the assessment of foveal avascular zone and macular structure in glaucoma.
Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo evaluate the association between foveal avascular zone (FAZ) parameters (area, perimeter and circularity) with macular high density perimetry (Octopus Macular program), macular vessel density (mVD) and ganglion cells layer thickness (GCLT) in glaucoma patients.
methodsThis cross-sectional study included 89 eyes from 57 glaucoma patients. All participants underwent high-density perimetry (Octopus 900 Macular and G programs). FAZ metrics and mVD were obtained via Optical Coherence Tomography Angiography (OCTA) (Triton, Topcon), and GCLT was measured across global, superior, and inferior sectors. FAZ parameters were automatically extracted using ImageJ with axial length correction. Structure-structure and structure-function associations were assessed using mixed-effects linear regression models, adjusting for inter-eye correlation, age, and GCLT when appropriate.
resultsMean age was 66.67 ± 7.49 years old. FAZ area and perimeter were significantly associated with mean defect of macular program (mMD), central mVD, and GCLT (p < 0.05). FAZ area remained significantly associated with GCLT even after controlling for age (p < 0.05). FAZ perimeter and circularity were independently associated with age. FAZ perimeter and circularity were mainly age-related, while area was linked to glaucomatous damage. FAZ parameters were more strongly related to superior than inferior GCLT. Glaucoma severity was categorized using Brusini's Glaucoma Staging System. Higher mMD values were observed in more advanced stages of glaucoma.
conclusionsFAZ morphology reflects both glaucomatous damage and age-related vascular changes. By controlling for confounding variables, this study reinforces the role of FAZ metrics as complementary biomarkers for assessing structure-function relationships in glaucoma. High-density macular perimetry further improves spatial correspondence with anatomical alterations.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.