ArticlePloS one2025
Intratympanic steroid administration and predictors of recovery in sudden sensorineural hearing loss.
Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Clinical effectiveness of salvage intratympanic corticosteroids for idiopathic sudden sensorineural hearing loss: a real-world observational series.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026Article
- Vitamin D and sudden sensorineural hearing loss: emerging associations, mechanistic insights, and prospects for precision medicine - a review.Frontiers in nutrition · 2026Review
- Efficacy of intratympanic methylprednisolone versus standard therapy in adult sudden sensorineural hearing loss.Frontiers in neurology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesSudden sensorineural hearing loss patient outcomes remain highly variable despite established treatment modalities. This study investigates the effects of treatment modalities, individual-level risk factors, and clinical presentation on sudden sensorineural hearing loss recovery.
methodsRetrospective chart review of n = 231 patients who initiated intratympanic steroids between 01/01/2015-01/01/2025 following sudden sensorineural hearing loss. We collected individual-level risk factors and comprehensive audiometric data. Logistic and linear regression analyses were performed to identify relationships between patient, disease, and treatment-related variables to audiometric recovery (pure-tone average and word recognition score). Segmented linear regression analysis was used to assess the influence of intratympanic steroid treatment delay on patient recovery. Recovery outcomes were determined in accordance with American Academy of Otolaryngology-Head and Neck Surgery criteria.
resultsEarlier intratympanic steroid initiation following sudden sensorineural hearing loss symptom onset significantly predicted increased pure-tone average recovery (p < 0.001) irrespective of intratympanic steroid status as primary treatment or as salvage therapy following oral steroids. Intratympanic steroid efficacy significantly diminished if initiated beyond 18 days following symptom onset (p < 0.001). Total number of intratympanic received and time between subsequent intratympanic injections did not impact recovery. Patient-level factors including demographics, socioeconomic status, medical and social risk factors, and medical comorbidities were largely found to have no significant relationship with recovery. Increased initial pure-tone average was associated with poorer overall pure-tone average recovery (p < 0.001). The presence of initial serviceable hearing predicted worse final recovery status (p = 0.01). Bilateral sudden sensorineural hearing loss showed significantly worse pure-tone average recovery compared to unilateral sudden sensorineural hearing loss (p = 0.04).
conclusionIntratympanic steroids are an effective treatment option for sudden sensorineural hearing loss. Clinicians should be mindful of intratympanic steroid initiation timing and case-specific factors that may influence sudden sensorineural hearing loss recovery when treating patients with sudden sensorineural hearing loss.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.