ArticleBiomacromolecules2025
Decoupling Bioactivity and Processability: RGD Click-Functionalized Coatings for a 3D-Printed PCL Scaffold.
Article in Biomacromolecules, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Construction, evaluation, and applications of renal barrier-on-a-chip system.Bioactive materials · 2026Review
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Authors and funding
10 authors.
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Abstract
The development of functionalized scaffolds with enhanced bioactivity remains a key challenge in bone tissue engineering (BTE). Here, we present a modular strategy to functionalize the surface of 3D-printed poly(ε-caprolactone) (PCL) scaffolds using an RGD-functionalized PCL derivative. A three-step synthesis introduced maleimide groups along the PCL backbone, enabling covalent conjugation of a thiol-containing peptide. The resulting polymer (PCL-AE-L) was applied via dip-coating, preserving the scaffold architecture and mechanical integrity while ensuring homogeneous surface coverage. Subsequent bioconjugation with the thiol-modified RGD peptide to obtain PCL@RGD scaffolds imparts enhanced cell-adhesive properties. Each functionalization step was confirmed by NMR, FTIR, DSC, GPC, and SEM-EDX analyses. Coating stability was demonstrated under simulated culture conditions. In vitro assays using SAOS-2 cells showed improved cell adhesion and mineralization of PCL@RGD compared to controls. This approach decouples bioactivity enhancement from the printing process and enables customizable surface functionalization, offering a versatile platform for developing next-generation scaffolds for regenerative medicine.
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