ArticleCell reports2025
Cohousing or cross-fostering followed by cohousing does not normalize the microbiomes of genetically distinct adult mice.
Article in Cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Glucuronolactone Promotes Mucin Sulfation to Alleviate Deoxynivalenol-Induced Intestinal Injury via Microbiota-Dependent and -Independent AHR Activation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- The intestinal microbiota impacts nutritional immunity and resistance toProceedings of the National Academy of Sciences of the United States of America · 2026Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
It is widely assumed that the horizontal transmission of microorganisms due to coprophagy or colonization of newborns normalizes the microbiomes of genetically distinct mice. Accordingly, cohousing animals of different genetic backgrounds or fostering them as neonates by the same females is commonly used for equilibrating microbial communities in laboratory mice. To assess whether these assumptions hold true under well-controlled experimental conditions, we analyze the composition of the gut commensal bacteria of adult mice from distinct genetic backgrounds either foster nursed by the same dams or cohoused as adults. Despite shared environmental conditions, significant differences in the gut bacterial profiles idiosyncratic to genetic backgrounds persist across all experiments. These findings indicate that host genetics play a crucial role in maintaining specific microbial communities in adult mice that cannot be permanently altered by either foster nursing or cohousing.
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