Observational studyThe international journal of cardiovascular imaging2025
Association between epicardial adipose tissue and transfusion-dependent β-thalassemia.
Observational study in The international journal of cardiovascular imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05508932 (Atrial Fibrillation in Beta-Thalassemia), which is not on this map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Atrial Fibrillation in Beta-Thalassemia
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0 citing papers in PubMed.
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Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEpicardial adipose tissue (EAT) is a fat depot with secretive and neuromodulative properties, involved in the pathogenesis of cardiovascular diseases. Transfusion-dependent β-thalassemia (TDβT) is an inherited disorder characterized by chronic anemia and at risk for the development of several comorbidities. Patients with TDβT have a higher incidence of cardiovascular diseases compared to the general population.
methodsThe aim of this study was to evaluate EAT thickness in a cohort of patients with TDβT (study group), compared to age- and sex-balanced patients with no TDβT (control group). Secondary endpoint included evaluation of differences in the regional distribution of EAT between patients with or without cardiovascular disease (NCT05508932).
resultsOverall, 272 patients were enrolled, of whom 136 in study group and 136 in control group. EAT thickness was significantly higher in the study group at left atrium, left atrioventricular groove and right atrioventricular groove compared to control group (4.2 vs. 3.0, 12.2 vs. 10.0 and 13.0 vs. 11.0 mm, respectively, p < 0.05 for all). Multivariable analysis confirmed an independent association between EAT and TDβT. The regional distribution of EAT showed significant differences between patients with or without atrial fibrillation, diabetes mellitus, stroke or heart failure.
conclusionsPatients with TDβT have higher values of EAT compared to controls with no TDβT.
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