Evidence map›Paper›PMID 41065874›Full record

ArticleMolecular biology reports2025

Piezo1 activator Yoda1 promotes protein anabolism in cultured murine myotubes.

Anastasia R Babkova, Natalia A Vilchinskaya, Ksenia V Sergeeva, Boris S Shenkman, Timur M Mirzoev

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Article in Molecular biology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Anastasia R BabkovaMyology Laboratory, Institute of Biomedical Problems, Russian Academy of Sciences, 123007, 76A Khoroshevskoe shosse, Moscow, Russia.
Natalia A VilchinskayaMyology Laboratory, Institute of Biomedical Problems, Russian Academy of Sciences, 123007, 76A Khoroshevskoe shosse, Moscow, Russia.
Ksenia V SergeevaMyology Laboratory, Institute of Biomedical Problems, Russian Academy of Sciences, 123007, 76A Khoroshevskoe shosse, Moscow, Russia.
Boris S ShenkmanMyology Laboratory, Institute of Biomedical Problems, Russian Academy of Sciences, 123007, 76A Khoroshevskoe shosse, Moscow, Russia.
Timur M MirzoevMyology Laboratory, Institute of Biomedical Problems, Russian Academy of Sciences, 123007, 76A Khoroshevskoe shosse, Moscow, Russia. tmirzoev@yandex.ru.ORCID http://orcid.org/0000-0002-1986-6221

Funding

Russian Science Foundation 22-75-10046
6 · The paper itself

Abstract

backgroundIn response to physical forces, skeletal muscles undergo a significant increase in protein anabolism. Piezo1 channels have emerged as key membrane mechanosensors in various tissues, including mammalian skeletal muscle. However, the potential role of Piezo1 channels in activating anabolic processes in muscle cells remains understudied. This study aimed to determine whether Yoda1, a specific Piezo1 activator, is able to promote protein anabolism in cultured skeletal muscle cells. METHODS AND

resultsC2C12 myotubes were treated with Yoda1 (a specific activator of Piezo1), gadolinium (Gd

conclusionOur findings show that Piezo1 activator Yoda1 is able to promote anabolic signaling and enhance PS rates in cultured mouse myotubes.

Indexed as

Ion ChannelsMuscle Fibers, SkeletalAnimalsCell LineGadoliniumGlycogen Synthase Kinase 3 betaMiceMuscle, SkeletalPhosphorylationProtein BiosynthesisProto-Oncogene Proteins c-aktPyrazinesSignal TransductionThiadiazolesGadoliniumGlycogen Synthase Kinase 3 betaIon ChannelsPiezo1 protein, mouseProto-Oncogene Proteins c-aktPyrazinesThiadiazolesyoda-1C2C12 myotubesGadoliniumGSK-3βP70S6KPiezo1Protein synthesisYoda1

Identifiers

PMID41065874

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.