Evidence map›Paper›PMID 41065870›Full record

ArticleJournal of neurology2025

Impact of device pass count and reperfusion levels in anterior circulation stroke: differential effects based on large-scale data from clinical practice.

Luca Meucci, Lukas Meyer, Gabriel Broocks, Matthias Bechstein, Christian Thaler, Christian Heitkamp, Laurens Winkelmeier, Vincent Geest, Alexander Heitkamp, Maximilian Jungnitz and 13 more

Erratum issuedAbstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Journal of neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

23 authors.

Luca MeucciDepartment of Diagnostic and Interventional Neuroradiology, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Germany. l.meucci@uke.de.ORCID http://orcid.org/0009-0009-7948-2746
Lukas MeyerDepartment of Diagnostic and Interventional Neuroradiology, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Germany.
Gabriel BroocksDepartment of Neuroradiology, HELIOS Medical Center, Campus of MSH Medical School Hamburg, Schwerin, Germany.
Matthias BechsteinDepartment of Diagnostic and Interventional Neuroradiology, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Germany.
Christian ThalerDepartment of Diagnostic and Interventional Neuroradiology, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Germany.
Christian HeitkampDepartment of Diagnostic and Interventional Neuroradiology, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Germany.
Laurens WinkelmeierDepartment of Diagnostic and Interventional Neuroradiology, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Germany.
Vincent GeestDepartment of Diagnostic and Interventional Neuroradiology, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Germany.
Alexander HeitkampDepartment of Diagnostic and Interventional Neuroradiology, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Germany.
Maximilian JungnitzDepartment of Diagnostic and Interventional Neuroradiology, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Germany.
Gregor PeterDepartment of Diagnostic and Interventional Neuroradiology, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Germany.
Felix SchlichtDepartment of Diagnostic and Interventional Neuroradiology, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Germany.
Jawed NawabiInstitute of Neuroradiology, Universitätsmedizin Berlin, Berlin, Germany.
Caspar BrekenfeldDepartment of Diagnostic and Interventional Neuroradiology, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Germany.
Máté E MarosDepartment of Biomedical Informatics, Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany.
Maximilian SchellDepartment of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Uta HanningDepartment of Neuroradiology, Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany.
Götz ThomallaDepartment of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Jens FiehlerDepartment of Diagnostic and Interventional Neuroradiology, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Germany.
Susanne GellißenDepartment of Diagnostic and Interventional Neuroradiology, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Germany.
Fabian Flottmann *Department of Diagnostic and Interventional Neuroradiology, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Germany.
Helge C Kniep *Department of Diagnostic and Interventional Neuroradiology, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Germany.
German Stroke Registry -Endovascular Treatment (GSR-ET)

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe relationship between angiographic success, number of device passes and functional outcome is a topic of clinical interest in endovascular thrombectomy (EVT) for acute ischemic stroke (AIS). This study systematically assessed differential effects of reperfusion levels and device pass counts based on large-scale, multicenter registry data.

methodsPatients enrolled in the prospective, multicenter German Stroke Registry between 06/2015-12/2023 were screened. Inclusion criteria were anterior circulation AIS, pre-stroke mRS of 0-1, ≥ 1 passes and availability of clinical data. The primary outcome was functional independence at 90 days. Outcomes were evaluated across different degrees of reperfusion and number of passes employing Inverse Probability Regression Adjustment to control for confounding factors.

results6,398 patients fulfilled the inclusion criteria. Single-pass mTICI 3 reperfusion was associated with the highest estimated rate of functional independence (54.3% [95% CI: 52.1-56.4]; p < 0.01) and the lowest mortality (19.6% [95% CI: 18.3-20.9]; p < 0.01) at 90 days. Up to three passes, mTICI 2b reperfusion achieved with n + 1 passes was associated with significantly better outcomes compared to mTICI 0-2a achieved with n passes. No significant difference in 90-day functional independence was observed between n pass mTICI 2b and n + 1 pass mTICI 3.

conclusionsThe highest rate of functional independence at 90 days was observed for single-pass mTICI 3 reperfusion. Up to three passes, achieving mTICI 2b with one additional pass was associated with improved outcomes compared to lower reperfusion grades. Improvement from mTICI 2b to 3 did not significantly increase outcomes.

Indexed as

Endovascular ProceduresIschemic StrokeRegistriesReperfusionThrombectomyAgedAged, 80 and overFemaleGermanyHumansMaleMiddle AgedProspective StudiesPassesReperfusionStrokeThrombectomy

Identifiers

PMID41065870

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.