ArticleWorld journal of urology2025
The prostatic inflammation score and risk of biochemical recurrence following radical prostatectomy.
Article in World journal of urology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The association between preoperative multiparametric MRI-defined prostatic apex shape and urinary continence recovery after radical prostatectomy: a systematic review and meta-analysis of comparative studies.World journal of surgical oncology · 2026Pooled it
- A novel positive surgical margin-based scoring system to predict oncologic outcomes after radical prostatectomy.BMC surgery · 2026Article
- Long-term transition of urinary status after robot-assisted radical prostatectomy.Journal of robotic surgery · 2026Article
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Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundInflammatory processes are thought to contribute to the development and progression of prostate cancer (PCa). This study aimed to evaluate whether a novel Prostatic Inflammation Score (PIS), integrating Irani Grade (G) and Aggressiveness (A), could predict the risk of biochemical recurrence (BCR) following radical prostatectomy (RP).
methodsPatients undergoing biopsy and RP between 2013 and 2023 were included. PIS was assessed on hematoxylin and eosin-stained biopsy cores: PIS 1 (G 0-1/A 0-1), PIS 2 (G 2-3/A 0-1), and PIS 3 (G 0-3/A 2-3). BCR, considered as two consecutive PSA readings of ≥ 0.2 ng/mL, was evaluated through multivariable Cox regression analysis.
resultsAmong 679 patients (median follow-up: 36 months), 127 (18.7%) experienced BCR. Over a median follow-up of 36 months, 127 (18.7%) patients experienced BCR. BCR incidence at six years was highest in PIS 1 (30%) vs. PIS 2 (10%) and PIS 3 (9%) (p = 0.002). Compared to PIS 1, hazard ratios (HR) for BCR were 0.44 (95% CI: 0.27-0.74) for PIS 2 and 0.37 (95% CI: 0.15-0.91) for PIS 3. IRANI G scores inversely correlated with BCR risk (HR = 0.44, 95% CI: 0.27-0.74), while IRANI A scores (2-3) showed a nonsignificant trend (HR = 0.41, 95% CI: 0.17-1.02, p = 0.054). Gleason grade and pT stage were significantly associated with BCR, while margin status and pN stage were not.
conclusionsPIS 1 was found to be associated with BCR after RP. Should these findings be externally validated, PIS could represent a readily available inexpensive tool to predict BCR after RP.
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