Evidence map›Paper›PMID 41065762›Full record

ArticleAnnals of African medicine2026

The Efficacy of Intrathecal Dexmedetomidine versus Fentanyl on Postoperative Pain: A Retrospective Study.

Mohammed I A Ismail, Lou'i Al-Husinat, Sarah Al Sharie, Mohammad Araydah, Abbas Baydoun, Zaid Al Modanat, Giovanna Grasso, Silvia Tripepi, Maria Rosaria Cuomo, Domenico Gammaldi and 5 more

Abstract readComparative Study
PubMed Full text at PMC Publisher
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Article in Annals of African medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

15 authors.

Mohammed I A IsmailDepartment of Anesthesiology, Mut'ah School of Medicine, Al-Karak, Jordan.
Lou'i Al-HusinatDepartment of Clinical Medical Sciences, Yarmouk University, Irbid, Jordan.
Sarah Al SharieDepartment of Faculty of Medicine, Yarmouk University, Irbid, Jordan.
Mohammad AraydahDepartment of Faculty of Medicine, Yarmouk University, Irbid, Jordan.
Abbas BaydounDepartment of Anesthesia, Abdulhadi General Hospital, Amman, Jordan.
Zaid Al ModanatDepartment of Clinical Medical Sciences, Yarmouk University, Irbid, Jordan.
Giovanna GrassoDepartment of Neuroscience, Azienda Ospedaliera Universitaria Federico II, Napoli, Italy.
Silvia TripepiDepartment of Anesthesia, Hospital San Giuseppe Moscati of Avellino, Avellino, Avellino, Italy.
Maria Rosaria CuomoDepartment of Anesthesia, the National Relief Hospital "Antonio Cardarelli" of Naples, Naples, Italy.
Domenico GammaldiDepartment of Anesthesiology and Intensive Care, Private Hospital Tortorella, Salerno, Italy.
Giustino VarrassiPain Medicine, Paolo Procacci Foundation, Rome, Italy.
Mohammed Wasfi AmirDepartment of Anesthesiology, Mut'ah School of Medicine, Al-Karak, Jordan.
Lana TalafhaDepartment of Faculty of Medicine, Yarmouk University, Irbid, Jordan.
Ismail M I IsmailFaculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan.
Antonella PaladiniDepartment of MESVA, University of L'Aquila, L'Aquila, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimsFor many surgical procedures, spinal anesthesia is a reliable and efficient anesthetic approach. Numerous drugs have been reported to be administered to intrathecal local anesthetics as adjuvants to increase the efficacy of spinal anes-thesia. There is little evidence of the effect of intrathecal dexmedetomidine on pain scores and the consumption of analgesia postoperatively.

methodsAfter obtaining ethical approval, demographical and clinical data of patients who underwent surgical procedures under spinal anesthesia with intrathecal dexmedetomidine or fentanyl was collected and analyzed.

resultsIn this study with 96 patients, intrathecal dexmedetomidine (group D) resulted in significantly lower post-operative pain scores com-pared to intrathecal fentanyl (group F) (p=0.000). Across various surgical types, including Orthopedic, General, Urology, and Obs/Gyne procedures, group D consistently displayed reduced pain scores (p <0.001). The number of patients who needed post-operative analgesia was significantly higher in group (F) than in group (D) (40 vs 23, P = 0.002).

conclusionCompared to fentanyl, intrathecal dexmedetomidine as an adjuvant to local anesthesia was found to lower post-operative pain scores and decrease the need for post-operative analgesia.

Indexed as

Analgesics, Non-NarcoticAnalgesics, OpioidAnesthesia, SpinalDexmedetomidineFentanylPostoperative PainAdultAnesthetics, LocalFemaleHumansInjections, SpinalMaleMiddle AgedPain MeasurementRetrospective StudiesTreatment OutcomeAnalgesics, Non-NarcoticAnalgesics, OpioidAnesthetics, LocalDexmedetomidineFentanylanesthésie rachidienneDexmedetomidinedexmédétomidinedouleur post-opératoirefentanylpostoperative painscore EVAspinal anesthesiaVisual Analog Scale score

Identifiers

PMID41065762
PMCPMC13374957

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