Evidence map›Paper›PMID 41065750›Full record

ArticleInorganic chemistry2025

Vertex Engineering of the Dodecaborate-Based Broadband Membrane Carriers.

Yueying Wang, Yessica A Nelson, Daniel F Torres Pomares, Cecilia M McCormick, Tyler A Kerr, Milan Gembicky, Alexander M Spokoyny

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Inorganic chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yueying WangDepartment of Chemistry and Biochemistry, University of California, Los Angeles, 607 Charles E. Young Drive East, Los Angeles, California 90095, United States.ORCID 0000-0002-4204-0065
Yessica A NelsonDepartment of Chemistry and Biochemistry, University of California, Los Angeles, 607 Charles E. Young Drive East, Los Angeles, California 90095, United States.
Daniel F Torres PomaresDepartment of Chemistry and Biochemistry, University of California, Los Angeles, 607 Charles E. Young Drive East, Los Angeles, California 90095, United States.
Cecilia M McCormickDepartment of Chemistry and Biochemistry, University of California, Los Angeles, 607 Charles E. Young Drive East, Los Angeles, California 90095, United States.
Tyler A KerrDepartment of Chemistry and Biochemistry, University of California, Los Angeles, 607 Charles E. Young Drive East, Los Angeles, California 90095, United States.ORCID 0000-0002-0369-4883
Milan GembickyDepartment of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, United States.ORCID 0000-0002-3898-1612
Alexander M SpokoynyDepartment of Chemistry and Biochemistry, University of California, Los Angeles, 607 Charles E. Young Drive East, Los Angeles, California 90095, United States.ORCID 0000-0002-5683-6240

Funding

Inorganic Chemistry Tools for Bioconjugation, Recognition and ImagingR35GM124746 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Alexander Michael Spokoyny · 2017 to 2026
$4.0M
NIGMS NIH HHS R35 GM124746
6 · The paper itself

Abstract

Perhalogenated boron clusters have been recently shown to possess promising membrane transport properties for a variety of cargo molecules; however, increased activity has also been correlated with notable toxicity, particularly in the case of iodinated variants. In this work, we report that replacing several of the halogen moieties with hydroxyl groups significantly reduces the cytotoxicity of the resulting perfunctionalized dodecaborate-based derivatives. Live cell imaging studies using a model peptide tagged with a fluorophore demonstrate that the transport potential of this new class of cluster-based carriers can be maintained even with vertex differentiation. Additional experiments using a lipophilic probe suggest that cluster-cargo interactions in solution can lead to altered delivery outcomes for certain dyes used in live cell staining.

Indexed as

Boron CompoundsDrug CarriersCell SurvivalFluorescent DyesHumansMolecular StructureBoron CompoundsdodecaborateDrug CarriersFluorescent Dyes

Identifiers

PMID41065750
PMCPMC12684814

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.