Evidence map›Paper›PMID 41065576›Full record

ArticleInternational journal of surgery (London, England)2026

Feasibility of robotic liver resection compared with laparoscopic and open liver resection for hepatocellular carcinoma: a network meta-analysis.

Sang-Hoon Kim, Ki-Hun Kim, Hugo Pinto-Marques, João Santos Coelho

Abstract readComparative StudyNetwork Meta-Analysis
In one paragraph

Article in International journal of surgery (London, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Sang-Hoon KimDivision of Liver Transplantation and Hepatobiliary Surgery, Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Ki-Hun KimDivision of Liver Transplantation and Hepatobiliary Surgery, Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.ORCID 0000-0002-4016-0995
Hugo Pinto-MarquesNOVA Medical School, Hepato-Biliary-Pancreatic and Transplantation Centre Curry Cabral Hospital/Local Health Unit of São José, Lisbon, Portugal.
João Santos CoelhoNOVA Medical School, Hepato-Biliary-Pancreatic and Transplantation Centre Curry Cabral Hospital/Local Health Unit of São José, Lisbon, Portugal.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRobotic liver resection (RLR) has gained popularity in the treatment of hepatocellular carcinoma (HCC); however, its efficacy compared to laparoscopic liver resection (LLR) and open liver resection (OLR) remains unclear.

methodsComprehensive literature search of electronic databases from January 2010 to December 2024 identified studies comparing RLR, LLR, or OLR. Operative, postoperative, and survival data were extracted, and pooled odd ratios or hazard ratios with 95% confidence intervals were calculated using a frequentist network meta-analysis including RLR, LLR, and OLR.

resultsA total of 69 studies, comprising 1 randomized controlled, 3 prospective, and 65 retrospective-matched studies, involving 13,257 patients were analyzed. This network meta-analysis showed that RLR had significantly lower blood loss than both OLR and LLR, with comparable operative time, RBC transfusion rates, Pringle maneuver use, Pringle time, and R1 resection rates. RLR showed similar rates of overall and major complications and hospital stay duration as LLR, with significant benefits over OLR. No significant differences in 90-day mortality were found among the three groups. For long-term outcomes, RLR showed no significant advantage over LLR or OLR in overall and recurrence-free survival, though it generally ranked higher with a greater P -score.

conclusionsThis network meta-analysis suggests that RLR is a feasible surgical treatment option for HCC, offering perioperative and long-term outcomes comparable to LLR, with reduced postoperative morbidity and shorter hospital stays compared to OLR. However, further studies are needed to confirm RLR's efficacy due to its limited sample size.

Indexed as

Carcinoma, HepatocellularHepatectomyLaparoscopyLiver NeoplasmsRobotic Surgical ProceduresBlood Loss, SurgicalFeasibility StudiesHumansLength of StayOperative TimePostoperative ComplicationsTreatment Outcomehepatocellular carcinomalaparoscopic liver resectionnetwork meta-analysisopen liver resectionrobotic liver resection

Identifiers

PMID41065576
PMCPMC12825750

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.