Evidence map›Paper›PMID 41065454›Full record

ArticleOrganic letters2025

Total Synthesis of Honokiol via Oxidative Phenol Coupling.

Emmanuel Moya Cruz, Young Eun Lee, Sun Min Kim, Stanislav Jaracz, Marisa C Kozlowski

Abstract read
In one paragraph

Article in Organic letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Emmanuel Moya CruzDepartment of Chemistry, Roy and Diana Vagelos Laboratories, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6323, United States.ORCID 0009-0008-8053-0306
Young Eun LeeDepartment of Chemistry, Roy and Diana Vagelos Laboratories, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6323, United States.ORCID 0009-0009-6199-898X
Sun Min KimDepartment of Chemistry, Roy and Diana Vagelos Laboratories, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6323, United States.
Stanislav JaraczColgate Palmolive Technology Center, 909 River Road, Piscataway, New Jersey 08854, United States.
Marisa C KozlowskiDepartment of Chemistry, Roy and Diana Vagelos Laboratories, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6323, United States.ORCID 0000-0002-4225-7125

Funding

Computation and Development of New, Enabling Synthetic MethodsR35GM131902 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI Marisa C Kozlowski · 2019 to 2026
$4.5M
NMR SYSTEMS : 2 BRUKER AVANCE 500 CONSOLESS10RR022442 · NCRR · UNIVERSITY OF PENNSYLVANIA · PI SMITH, AMOS B · 2006 to 2006
$500k
Purchase of a Mass Directed Liquid ChromatographS10OD011980 · OD · UNIVERSITY OF PENNSYLVANIA · PI KOZLOWSKI, MARISA C · 2012 to 2012
$372k
Time-Of-Flight Instrument with Variable Ionization SourcesS10RR023444 · NCRR · UNIVERSITY OF PENNSYLVANIA · PI DMOCHOWSKI, IVAN JULIAN · 2007 to 2007
$308k
NCRR NIH HHS S10 RR022442NCRR NIH HHS S10 RR023444NIGMS NIH HHS R35 GM131902NIH HHS S10 OD011980
6 · The paper itself

Abstract

Herein we disclose the total synthesis of honokiol in six steps in an overall yield of 66%. Two distinct routes were explored, with the key steps being highly efficient and selective cross-couplings of commercially available phenols to construct the main biphenolic backbone. The routes employ inexpensive reagents and are scalable, high-yielding processes. The experimental procedures are reported in the conventional narrative format and two machine-readable formats.

Identifiers

PMID41065454
PMCPMC13130584

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.