Evidence map›Paper›PMID 41065414›Full record

ArticleMicrobiology spectrum2025

Comparative gene expression analysis in closely related dermatophytes reveals secondary metabolism as a candidate driver of virulence.

Lenka Machová, Martin Kostovčík, Karel Švec, Vít Hubka, Miroslav Kolařík, Adéla Wennrich

Abstract readComparative Study
In one paragraph

Article in Microbiology spectrum, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Dermatophytosis: An Update on Global Epidemiology.Journal of fungi (Basel, Switzerland) · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Lenka MachováLaboratory of Fungal Genetics and Metabolism, Institute of Microbiology, Czech Academy of Sciences, Prague, Czech Republic.ORCID 0009-0008-1447-3593
Martin KostovčíkLaboratory of Fungal Genetics and Metabolism, Institute of Microbiology, Czech Academy of Sciences, Prague, Czech Republic.ORCID 0000-0001-6982-1470
Karel ŠvecLaboratory of Fungal Genetics and Metabolism, Institute of Microbiology, Czech Academy of Sciences, Prague, Czech Republic.ORCID 0000-0002-0077-8539
Vít HubkaLaboratory of Fungal Genetics and Metabolism, Institute of Microbiology, Czech Academy of Sciences, Prague, Czech Republic.
Miroslav KolaříkLaboratory of Fungal Genetics and Metabolism, Institute of Microbiology, Czech Academy of Sciences, Prague, Czech Republic.ORCID 0000-0003-4016-0335
Adéla WennrichLaboratory of Fungal Genetics and Metabolism, Institute of Microbiology, Czech Academy of Sciences, Prague, Czech Republic.ORCID 0000-0002-7986-6688

Funding

Czech Academy of Sciences AV21 Program, CAS (VP33)Czech Academy of Sciences LQ200202501Czech Academy of Sciences RVO: 61388971Ministry of Education CZ.02.01.01/00/22_008/0004597
6 · The paper itself

Abstract

Dermatophytes are important fungal skin pathogens affecting humans and animals worldwide. Although several virulence factors have been identified using genomic, proteomic, and transcriptomic approaches, their roles remain incompletely understood. In this study, we applied a comparative approach using four closely related taxa within the

Indexed as

ArthrodermataceaeSecondary MetabolismTrichophytonAnimalsFungal ProteinsGene Expression ProfilingGene Expression Regulation, FungalHumansMiceSkinVirulenceVirulence FactorsFungal ProteinsVirulence Factorsdermatophytesex vivo skin modelgene expressionRT-qPCRsecondary metabolitesTrichophyton benhamiae complexvirulence factors

Identifiers

PMID41065414
PMCPMC12584700

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.